Lipooligosaccharide locus classes are associated with certain Campylobacter jejuni multilocus sequence types

The lipooligosaccharide (LOS) locus class was determined using polymerase chain reaction (PCR) in 335 Finnish Campylobacter jejuni strains isolated from humans, poultry and bovines with known multilocus sequence types. The results revealed an association between clonal complexes/sequence types (STs)...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2012-09, Vol.31 (9), p.2203-2209
Main Authors: Revez, J., Hänninen, M.-L.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Biosynthesis
Campylobacter
Campylobacter Infections - microbiology
Campylobacter Infections - veterinary
Campylobacter jejuni
Campylobacter jejuni - classification
Campylobacter jejuni - genetics
Campylobacter jejuni - isolation & purification
Cattle
Epidemiology
Finland
Genes
Humans
Infection
Infections
Infectious diseases
Internal Medicine
Lipooligosaccharides
Lipopolysaccharides - genetics
Medical Microbiology
Medical sciences
Molecular Epidemiology - methods
Multilocus Sequence Typing
Polymerase Chain Reaction
Poultry
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Summary:The lipooligosaccharide (LOS) locus class was determined using polymerase chain reaction (PCR) in 335 Finnish Campylobacter jejuni strains isolated from humans, poultry and bovines with known multilocus sequence types. The results revealed an association between clonal complexes/sequence types (STs) and LOS locus classes. Based on these results, we further predicted the LOS locus classes distribution among the STs of 209 additional C. jejuni strains from Finnish human domestically acquired infections. Non-sialylated LOS locus classes were associated with STs that comprised ≈55% of patient strains. Sialylated LOS locus classes A and B were associated with STs infrequently isolated, whereas class C was correlated with the ST-21 complex, found in ≈14% of human strains. A combination of the LOS locus class and multilocus sequence type may provide new information on the epidemiology and association of C. jejuni strains with certain disease outcomes.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-012-1556-3