In vitro and in vivo anthelmintic activity of Euphorbia helioscopia L

The anthelmintic potentials of the aqueous and methanol extracts of Euphorbia helioscopia were investigated. In folklore medicine, E. helioscopia (Euphorbiaceae) is used in the treatment of various gastrointestinal ailments and diseases. A worm motility inhibition (WMI) assay and egg hatch assay (EH...

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Bibliographic Details
Published in:Veterinary parasitology 2012-10, Vol.189 (2-4), p.317-321
Main Authors: Lone, Bashir A., Chishti, M.Z., Bhat, Fayaz Ahmad, Tak, Hidayatullah, Bandh, Suhaib A.
Format: Article
Language:English
Subjects:
aerial parts
Animals
Anthelmintic
Anthelmintics - chemistry
Anthelmintics - pharmacology
Anthelmintics - therapeutic use
digestive system diseases
eggs
Euphorbia
Euphorbia - chemistry
Euphorbia helioscopia
fecal egg count
Feces - parasitology
Female
flowers
Haemonchus contortus
hatching
In vitro
in vitro studies
In vivo
in vivo studies
Kashmir
leaves
levamisole
Male
medicine
methanol
paralysis
Parasite Egg Count
Plant Extracts - chemistry
Plant Extracts - pharmacology
ruminants
Sheep
Sheep Diseases - drug therapy
Sheep Diseases - parasitology
stems
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Summary:The anthelmintic potentials of the aqueous and methanol extracts of Euphorbia helioscopia were investigated. In folklore medicine, E. helioscopia (Euphorbiaceae) is used in the treatment of various gastrointestinal ailments and diseases. A worm motility inhibition (WMI) assay and egg hatch assay (EHA) were used for in vitro assessment, and a faecal egg count reduction (FECR) assay was used for an in vivo study. The in vitro study revealed anthelmintic effects of crude methanolic extracts of E. helioscopia on live Haemonchus contortus worms as evident from their paralysis and/or death at 8h after exposure, different concentrations (12.5mgml−1, 25mgml−1 and 50mgml−1) of aqueous and methanolic extracts were used against H. contortus which exhibited dose-dependent anthelmintic effects on H. contortus. Aqueous and methanolic extracts of aerial parts (stem, leaves and flowers) of E. helioscopia were found to have very low percent inhibitory egg hatching as compared to levamisole. It is concluded that the entire plant of E. helioscopia possesses significant anthelmintic activity and could be a potential alternative for treating cases of helminth infections in ruminants.
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2012.04.023