Plasma Adrenomedullin and Subclinical Cardiorenal Syndrome in Patients with Type 2 Diabetes Mellitus

OBJECTIVE: To evaluate whether plasma adrenomedullin is involved in the previously reported significant inverse correlation between left ventricular (LV) end-diastolic pressure (peak velocity of early transmitral flow/peak velocity of early diastolic mitral annular motion ratio [E/E′]) and estimated...

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Bibliographic Details
Published in:Journal of international medical research 2012, Vol.40 (4), p.1552-1559
Main Authors: Pecková, M, Charvat, J, Schuck, O, Zamrazil, V, Bilek, R, Hill, M, Svab, P, Horackova, M
Format: Article
Language:English
Subjects:
Adrenomedullin - blood
Aged
Cardio-Renal Syndrome - blood
Cardio-Renal Syndrome - etiology
Cardio-Renal Syndrome - physiopathology
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Female
Glomerular Filtration Rate
Humans
Linear Models
Male
Middle Aged
Multivariate Analysis
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - physiopathology
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Summary:OBJECTIVE: To evaluate whether plasma adrenomedullin is involved in the previously reported significant inverse correlation between left ventricular (LV) end-diastolic pressure (peak velocity of early transmitral flow/peak velocity of early diastolic mitral annular motion ratio [E/E′]) and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus, mild-to-moderate renal function impairment and LV relaxation impairment (E′ ≤ 7.1 cm/s). METHODS: Plasma adrenomedullin concentration, E/E′ and eGFR were assessed in 82 patients with type 2 diabetes. RESULTS: Plasma adrenomedullin concentration was positively correlated with eGFR in patients with or without LV relaxation impairment, and inversely correlated with E/E′ in patients with LV relaxation impairment. Multivariate linear regression analysis supported a role for plasma adrenomedullin in the association between E/E′ and eGFR. CONCLUSION: These results support the hypothesis that adrenomedullin modulates the interaction between the heart and kidneys in early subclinical cardiorenal syndrome in patients with type 2 diabetes mellitus.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323001204000435