Pre-operative predictors of post-hepatectomy recurrence of hepatocellular carcinoma: Can we predict earlier?

Abstract Backgrounds and purpose To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC). Methods From January 2001 to July 2007, all patients having hepatectomy for first occurrence HCC with curative intent were identified from a pros...

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Bibliographic Details
Published in:The surgeon (Edinburgh) 2012-10, Vol.10 (5), p.260-266
Main Authors: Chong, Charing Ching-Ning, Lee, Kit-fai, Ip, Philip Ching-Tak, Wong, Jeff Siu-Wang, Cheung, Sunny Yue-Sun, Wong, John, Ho, Suzanne C, Lai, Paul Bo-San
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - surgery
Female
Hepatectomy
Hepatocellular carcinoma
Humans
Kaplan-Meier Estimate
Liver Neoplasms - mortality
Liver Neoplasms - surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local - diagnosis
Predictors
Prognosis
Recurrence
Retrospective Studies
Risk Factors
Surgery
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Summary:Abstract Backgrounds and purpose To determine the predictors for recurrence in patients receiving curative hepatectomy for hepatocellular carcinoma (HCC). Methods From January 2001 to July 2007, all patients having hepatectomy for first occurrence HCC with curative intent were identified from a prospectively collected database. Prognostic factors for recurrence and survival after resection were analyzed. Results A total of 235 patients were included. With a median follow-up of 50.2 (0.07–125.1) months, the recurrence rate was 57.0%. The 1-, 3-, and 5-year overall survival rates were 83.9%, 66.0%, and 58.1% respectively. Multivariate analysis demonstrated that multi-focal lesions (HR: 2.93, P  
ISSN:1479-666X
2405-5840
DOI:10.1016/j.surge.2011.07.004