Hemodynamic differences between the awake and anesthetized conditions in normal calves

There is insufficient information in the literature about baseline circulatory parameters in normal calves in the anesthetized versus postoperative awake conditions under which a large volume of medical research is conducted. Eleven calves (mean body weight, 78.1 ± 14.3 kg) were implanted with a flo...

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Bibliographic Details
Published in:Journal of artificial organs 2012-09, Vol.15 (3), p.225-230
Main Authors: Takaseya, Tohru, Fujiki, Masako, Shiose, Akira, Kim, Hyun-Il, Kobayashi, Mariko, Massiello, Alex L., Dessoffy, Raymond, Al-Ruzzeh, Sharif, Fukamachi, Kiyotaka
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Biomedical Engineering and Bioengineering
Blood Pressure - physiology
Cardiac Output - physiology
Cardiac Surgery
Cattle
Hemodynamics - physiology
Isoflurane - administration & dosage
Medicine
Medicine & Public Health
Nephrology
Original Article
Vascular Resistance - physiology
Wakefulness - physiology
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Summary:There is insufficient information in the literature about baseline circulatory parameters in normal calves in the anesthetized versus postoperative awake conditions under which a large volume of medical research is conducted. Eleven calves (mean body weight, 78.1 ± 14.3 kg) were implanted with a flow probe and fluid-filled pressure lines to measure cardiac output (CO), aortic (AoP), central venous (CVP), pulmonary arterial (PAP), and left atrial pressures (LAP). Systemic (SVR) and pulmonary vascular resistance (PVR) were also calculated. We obtained the above hemodynamic data ( n  = 11) and epicardial echocardiography ( n  = 7) during open-chest surgery under isoflurane anesthesia. After full recovery from surgery, animals were evaluated in the awake condition on postoperative days 6–9 using transthoracic echocardiography ( n  = 7) and the hemodynamic monitoring lines and probes noted ( n  = 11). CO, AoP, and PAP levels in the anesthetized condition were significantly lower than in the awake condition. Other hemodynamic parameters (CVP, LAP, SVR, and PVR) were not significantly different. In conclusion, data from this study quantify changes in CO, AoP, and PAP in anesthetized calves that may affect the hemodynamic response to experimental therapeutics such as new cardiac assist devices, prosthetic valves, and surgical interventions. Our study also provides baseline data for the translation of the hemodynamic data obtained in acute in vivo calf studies to that of an awake subject.
ISSN:1434-7229
1619-0904
DOI:10.1007/s10047-012-0636-6