Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types

The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requ...

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Bibliographic Details
Published in:Cell stem cell 2012-08, Vol.11 (2), p.147-152
Main Authors: Taylor, Craig J., Peacock, Sarah, Chaudhry, Afzal N., Bradley, J. Andrew, Bolton, Eleanor M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Donors
Fundamental and applied biological sciences. Psychology
Graft rejection
Histocompatibility antigen HLA
Histocompatibility Testing
HLA Antigens - immunology
Humans
Immunosuppression
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - immunology
Inhibitory postsynaptic potentials
Molecular and cellular biology
Stem Cell Transplantation - methods
Stem cells
Tissue Donors
Tissue typing
Transplantation, Homologous
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Summary:The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2012.07.014