Evaluation of α-d-ribofuranose (d-ribose) toxicity after intravenous administration to rabbits

Rapid intravenous administration of d-ribose may result in a significant reduction in cellular damage in patients with sudden ischemic insults. The development of an effective and clinically safe therapeutic regimen using the intravenous route in critically ill patients especially with cardiac disea...

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Bibliographic Details
Published in:Human & experimental toxicology 2012-08, Vol.31 (8), p.820-829
Main Authors: Ismail, Z Bani, Abu-Baker, N, Alzoubi, K, Al-Zhgoul, M, Al-Essa, MK, Khlouf, S, Al-Saleh, A, Al-Omari, B, Abu-Tayeh, R, Shomaf, M, Battah, A, Al-Hadidi, K
Format: Article
Language:English
Subjects:
Administration, Intravenous
Animals
Biological and medical sciences
D-Ribose
Drug development
Drug toxicity and drugs side effects treatment
Drugs
Female
Heart diseases
Intravenous administration
Ischemia
Laboratory animals
Leukocyte Count
Leukocytes (neutrophilic)
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Neutrophils - cytology
Neutrophils - drug effects
Pharmacology. Drug treatments
Protective Agents - administration & dosage
Protective Agents - toxicity
Rabbits
Ribose - administration & dosage
Ribose - toxicity
Statistical analysis
Toxicity
Toxicity Tests, Subacute
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Summary:Rapid intravenous administration of d-ribose may result in a significant reduction in cellular damage in patients with sudden ischemic insults. The development of an effective and clinically safe therapeutic regimen using the intravenous route in critically ill patients especially with cardiac diseases requires a comprehensive assessment of potential toxic effects of the drug in laboratory animals and in human beings. The potential clinical, behavioral, hematological, biochemical, gross pathological and histological toxic effects associated with the intravenous administration of d-ribose in rabbits for 28 days were evaluated in this study. Except for an increase in neutrophil percentage in male rabbits in the d-ribose-treated groups, there were no statistically significant toxic effects induced by daily intravenous administration of the drug in male and female rabbits. Results of this study suggest that d-ribose administered intravenously for 28 days in the rabbit exhibited no toxicity at 420 mg/kg.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327111432505