Multiple anatomical systems embedded within the primate medial temporal lobe: implications for hippocampal function

A review of medial temporal lobe connections reveals three distinct groupings of hippocampal efferents. These efferent systems and their putative memory functions are: (1) The 'extended-hippocampal system' for episodic memory, which involves the anterior thalamic nuclei, mammillary bodies...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2012-08, Vol.36 (7), p.1579-1596
Main Author: Aggleton, John P
Format: Article
Language:English
Subjects:
Amygdala
Animals
Cortex (prefrontal)
Cortex (somatosensory)
Cortex (subicular)
Cortex (temporal)
Familiarity
Hippocampus
Hippocampus - anatomy & histology
Hippocampus - physiology
Humans
Information processing
Memory
Memory - physiology
Nervous system
Neural Pathways - physiology
Nucleus accumbens
Parahippocampal Gyrus - anatomy & histology
Parahippocampal Gyrus - physiology
Primates
Primates - physiology
Sensory integration
Temporal lobe
Temporal Lobe - physiology
Thalamic nuclei
Thalamus
Topography
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Summary:A review of medial temporal lobe connections reveals three distinct groupings of hippocampal efferents. These efferent systems and their putative memory functions are: (1) The 'extended-hippocampal system' for episodic memory, which involves the anterior thalamic nuclei, mammillary bodies and retrosplenial cortex, originates in the subicular cortices, and has a largely laminar organisation; (2) The 'rostral hippocampal system' for affective and social learning, which involves prefrontal cortex, amygdala and nucleus accumbens, has a columnar organisation, and originates from rostral CA1 and subiculum; (3) The 'reciprocal hippocampal-parahippocampal system' for sensory processing and integration, which originates from the length of CA1 and the subiculum, and is characterised by columnar, connections with reciprocal topographies. A fourth system, the 'parahippocampal-prefrontal system' that supports familiarity signalling and retrieval processing, has more widespread prefrontal connections than those of the hippocampus, along with different thalamic inputs. Despite many interactions between these four systems, they may retain different roles in memory which when combined explain the importance of the medial temporal lobe for the formation of declarative memories.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2011.09.005