Intrauterine growth restriction leads to changes in sulfur amino acid metabolism, but not global DNA methylation, in Yucatan miniature piglets

Intrauterine growth restriction (IUGR), in both animals and humans, has been linked to metabolic syndrome later in life. There has been recent evidence that perturbations in sulfur amino acid metabolism may be involved in this early programming phenomenon. Methionine is the precursor for cellular me...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2012-09, Vol.23 (9), p.1121-1127
Main Authors: MacKay, Dylan S, Brophy, Julie D, McBreairty, Laura E, McGowan, Ross A, Bertolo, Robert F
Format: Article
Language:English
Subjects:
adults
amino acid metabolism
Amino acid sequence
Amino acids
Amino Acids, Sulfur - metabolism
Animals
Animals, Inbred Strains
Animals, Newborn
Betaine-homocysteine S-methyltransferase
Betaine-Homocysteine S-Methyltransferase - genetics
Betaine-Homocysteine S-Methyltransferase - metabolism
Biological and medical sciences
cystathionine
Cystathionine gamma-Lyase - genetics
Cystathionine gamma-Lyase - metabolism
Cysteine
Disease Models, Animal
DNA Methylation
Early origins of adult diseases
Enzyme activity
Enzymes
Epigenesis, Genetic
Epigenetics
Feeding. Feeding behavior
Fetal Growth Retardation - enzymology
Fetal Growth Retardation - metabolism
Fetal Growth Retardation - pathology
Fetuses
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Enzymologic
Homocysteine
Humans
Liver
Liver - enzymology
Liver - metabolism
Liver - pathology
Male
messenger RNA
Metabolic disorders
metabolic syndrome
Metabolites
Methionine
Methylation
miniature swine
mRNA
Neonates
Organ Size
piglets
prenatal development
RNA, Messenger - metabolism
Sulfur
Swine
Swine, Miniature
Taurine
Taurine - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Intrauterine growth restriction (IUGR), in both animals and humans, has been linked to metabolic syndrome later in life. There has been recent evidence that perturbations in sulfur amino acid metabolism may be involved in this early programming phenomenon. Methionine is the precursor for cellular methylation reactions and for the synthesis of cysteine. It has been suggested that the mechanism behind the “fetal origins” of adult diseases may be epigenetic, involving DNA methylation. Because we have recently demonstrated the fetal origins phenomenon in Yucatan miniature swine, we hypothesized that sulfur amino acid metabolism is altered in IUGR piglets. In this study, metabolites and the activities of sulfur amino acid cycle enzymes were analyzed in liver samples of 3- to 5-day-old runt (IUGR: 0.85±0.13 kg) and large (1.36±0.21 kg) Yucatan miniature pig littermates (n=6 pairs). The IUGR piglets had significantly lower specific and total activities of betaine-homocysteine methyltransferase (BHMT) and cystathionine γ-lyase (CGL) than larger littermates (P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2011.06.005