Quantitative studies of lower motor neuron degeneration in amyotrophic lateral sclerosis: Evidence for exponential decay of motor unit numbers and greatest rate of loss at the site of onset

Abstract Objective To use our Bayesian method of motor unit number estimation (MUNE) to evaluate lower motor neuron degeneration in ALS. Methods In subjects with ALS we performed serial MUNE studies. We examined the repeatability of the test and then determined whether the loss of MUs was fitted by...

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Bibliographic Details
Published in:Clinical neurophysiology 2012-10, Vol.123 (10), p.2092-2098
Main Authors: Baumann, F, Henderson, R.D, Gareth Ridall, P, Pettitt, A.N, McCombe, Pamela A
Format: Article
Language:English
Subjects:
Adult
Aged
ALS
Amyotrophic Lateral Sclerosis - pathology
Bayes Theorem
Biological and medical sciences
Electrodiagnosis. Electric activity recording
Female
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Mathematical models
Median Nerve - pathology
Medical sciences
Middle Aged
Models, Theoretical
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Motor Neurons - pathology
Motor unit
MUNE
Nerve Degeneration - pathology
Nervous system
Neurology
Peroneal Nerve - pathology
Ulnar Nerve - pathology
Vertebrates: nervous system and sense organs
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Summary:Abstract Objective To use our Bayesian method of motor unit number estimation (MUNE) to evaluate lower motor neuron degeneration in ALS. Methods In subjects with ALS we performed serial MUNE studies. We examined the repeatability of the test and then determined whether the loss of MUs was fitted by an exponential or Weibull distribution. Results The decline in motor unit (MU) numbers was well-fitted by an exponential decay curve. We calculated the half life of MUs in the abductor digiti minimi (ADM), abductor pollicis brevis (APB) and/or extensor digitorum brevis (EDB) muscles. The mean half life of the MUs of ADM muscle was greater than those of the APB or EDB muscles. The half-life of MUs was less in the ADM muscle of subjects with upper limb than in those with lower limb onset. Conclusions The rate of loss of lower motor neurons in ALS is exponential, the motor units of the APB decay more quickly than those of the ADM muscle and the rate of loss of motor units is greater at the site of onset of disease. Significance This shows that the Bayesian MUNE method is useful in following the course and exploring the clinical features of ALS.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2012.03.007