Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymers

Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lun...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-03, Vol.48 (21), p.2668-2670
Main Authors: Liu, Demin, Kramer, Stephanie A, Huxford-Phillips, Rachel C, Wang, Shunzhi, Della Rocca, Joseph, Lin, Wenbin
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - pharmacology
Calcium - chemistry
Cancer
Cell Line, Tumor
Cell Survival - drug effects
Coordination polymers
Diphosphonates - chemistry
Diphosphonates - pharmacology
Human
Humans
Imidazoles - chemistry
Imidazoles - pharmacology
Ligands
Lipid Bilayers - metabolism
Lipids
Nanocomposites
Nanomaterials
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanostructure
Pamidronate
Polymers - chemistry
Zoledronic Acid
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Summary:Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lung and pancreatic cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc17635a