Carbon nanoparticles and a new derivative of hydroquinone for modification of a carbon paste electrode for simultaneous determination of epinephrine and acetaminophen

A carbon paste electrode modified with a novel derivative of hydroquinone (DH), 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]-bishydroquinone , has been used to study the electrocatalytic oxidation of epinephrine (EP). In this work carbon nanoparticles (CNs) were used for improvement of electroc...

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Published in:Analytical methods 2012-07, Vol.4 (7), p.2127-2133
Main Authors: Mazloum-Ardakani, Mohammad, Rajabzadeh, Nooshin, Dehghani -Firouzabadi, Afsaneh, Sheikh-Mohseni, Mohammad Ali, Benvidi, Ali, Naeimi, Hossein, Akbari, Marzieh, Karshenas, Azam
Format: Article
Language:English
Subjects:
Carbon
Derivatives
Electrodes
Epinephrine
Mathematical analysis
Pastes
Rate constants
Voltammetry
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Summary:A carbon paste electrode modified with a novel derivative of hydroquinone (DH), 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]-bishydroquinone , has been used to study the electrocatalytic oxidation of epinephrine (EP). In this work carbon nanoparticles (CNs) were used for improvement of electrochemical properties. The apparent charge transfer rate constant, k sub(s) = 2.03 plus or minus 0.15 s super(-1), and transfer coefficient, alpha = 0.46, for electron transfer between the modifier and the carbon paste electrode were calculated. It has been found that under an optimum condition (pH = 7.0) in cyclic voltammetry, the oxidation of EP occurs at a potential about 222 mV less positive than that of an unmodified carbon paste electrode. The values of the transfer coefficient ( alpha = 0.46), catalytic rate constant (k= 5.03 10 super(3) M super(-1) s super(-1)) and diffusion coefficient (D= 4.67 10 super(-6) cm super(2) s super(-1)) were calculated for EP. Differential pulse voltammetry (DPV) exhibited two linear dynamic ranges of 5.0 to 20.0 mu M and 20.0 to 600.0 mu M for EP. This modified electrode was quite effective not only to detect EP and acetaminophen (AC) but also in simultaneous determination of these species in a mixture. The lower limits of detection for EP and AC are obtained as 1.0 and 12.0 mu M, respectively.
ISSN:1759-9660
1759-9679
DOI:10.1039/c2ay25063b