Solubilisation capacity of Brij surfactants

The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities of other poly(ethylene oxid...

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Bibliographic Details
Published in:International journal of pharmaceutics 2012-10, Vol.436 (1-2), p.631-635
Main Authors: Ribeiro, Maria E.N.P., de Moura, Carolina L., Vieira, Mariano G.S., Gramosa, Nilce V., Chaibundit, Chiraphon, de Mattos, Marcos C., Attwood, David, Yeates, Stephen G., Nixon, S. Keith, Ricardo, Nágila M.P.S.
Format: Article
Language:English
Subjects:
Block copolymers
Brij surfactants
composite polymers
drugs
ethylene oxide
Griseofulvin
Griseofulvin - chemistry
hydrophilicity
Micelles
nuclear magnetic resonance spectroscopy
Plant Oils - chemistry
Polyethylene Glycols - chemistry
Solubilisation
Solubility
solubilization
Surface-Active Agents - chemistry
surfactants
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Summary:The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities of other poly(ethylene oxide)-based copolymers. UV/Vis and 1H NMR spectroscopies were used to quantify the enhancement of solubility of griseofulvin in 1wt% aqueous micellar solutions of Brij 78 (C18H37E20), Brij 98 (C18H35E20) and Brij 700 (C18H37E100) (where E represents the OCH2CH2 unit of the poly(ethylene oxide) chain) at 25, 37 and 40°C. Solubilisation capacities (Scp expressed as mg griseofulvin per g Brij) were similar for Brij 78 and 98 (range 6–11mgg−1) but lower for Brij 700 (3–4mgg−1) as would be expected for the surfactant with the higher ethylene oxide content. The drug loading capacity of micelles of Brij 78 was higher than many di- and triblock copolymers with hydrophilic E-blocks specifically designed for enhancement of drug solubility.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2012.07.032