Clinicopathologic characteristics of patients with non-B non-C hepatitis virus hepatocellular carcinoma after hepatectomy

Abstract Background A substantial population of hepatocellular carcinoma (HCC) patients is negative for markers of hepatitis B virus and hepatitis C virus (HCV) infection (non-B non-C hepatitis virus [NBC]). Methods Clinicopathologic data and outcomes were compared retrospectively for HCC patients w...

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Bibliographic Details
Published in:The American journal of surgery 2012-09, Vol.204 (3), p.300-307
Main Authors: Kaibori, Masaki, M.D, Ishizaki, Morihiko, M.D, Matsui, Kosuke, M.D, Kwon, A-Hon, M.D
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers - blood
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Des-gamma-carboxy prothrombin
Disease-Free Survival
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Hepatectomy
Hepatitis
Histology
Humans
Infections
Kaplan-Meier Estimate
Liver cancer
Liver cirrhosis
Liver Neoplasms - blood
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical imaging
Medical sciences
Middle Aged
Mortality
Multivariate analysis
Non-B non-C hepatocellular carcinoma
Other diseases. Semiology
Prognosis
Protein Precursors - blood
Prothrombin
Retrospective Studies
Risk Factors
Standard deviation
Studies
Surgery
Tomography
Transplants & implants
Treatment Outcome
Tumors
Viral infections
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Summary:Abstract Background A substantial population of hepatocellular carcinoma (HCC) patients is negative for markers of hepatitis B virus and hepatitis C virus (HCV) infection (non-B non-C hepatitis virus [NBC]). Methods Clinicopathologic data and outcomes were compared retrospectively for HCC patients with hepatitis B virus, HCV, and NBC who had undergone hepatectomy. Results The TNM stage was significantly higher, and the prevalence of cirrhosis was significantly lower, in the NBC group compared with the HCV group. Among patients with a maximum tumor diameter of 5 cm or less, the survival rates were significantly higher in the NBC group than in the HCV group. Multivariate analysis revealed that preoperative serum des-gamma-carboxy prothrombin (DCP) level was a prognostic factor for survival in NBC–HCC patients. The DCP/tumor size ratio was significantly higher in NBC–HCC patients with normal liver histology than in patients with hepatitis or cirrhosis. Conclusions NBC–HCC patients had more advanced tumors compared with HCV–HCC patients, but significantly higher survival rates. Measurement of DCP potentially is significant for early diagnosis of NBC HCC, which may increase the chance of curative therapy without recurrence.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2011.11.014