Antiepileptic drugs and vitamin B6 plasma levels in adult patients

Summary Treatment with several antiepileptic drugs (AED) is associated with lower serum concentrations of folate or vitamin B12. This prospective monocenter study analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated ( n = 385), untreated ( n = 15) and healthy controls (...

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Bibliographic Details
Published in:Epilepsy research 2012-08, Vol.101 (1), p.182-184
Main Authors: Linnebank, Michael, Moskau, Susanna, Semmler, Alexander, Widman, Guido, Weller, Michael, Kallweit, Ulf, Elger, Christian E
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - adverse effects
Anticonvulsants. Antiepileptics. Antiparkinson agents
Antiepileptic drugs
Biological and medical sciences
Epilepsy - blood
Epilepsy - drug therapy
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Prospective Studies
Vitamin B 6 - blood
Vitamin B6
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Summary:Summary Treatment with several antiepileptic drugs (AED) is associated with lower serum concentrations of folate or vitamin B12. This prospective monocenter study analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated ( n = 385), untreated ( n = 15) and healthy controls ( n = 233). The mean plasma vitamin B6 levels of the AED-treated (12.1 ± 10.1; p = 0.093) and the untreated patients (15.6 ± 12.4; p = 0.664) were not significantly different from the controls (13.9 ± 15.2). These observations do not support the hypothesis that vitamin B6 blood levels are influenced by AED treatment.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2012.03.002