Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse

Objective To identify an antibody biomarker for multiple sclerosis (MS) that can be used as a predictor of MS relapses. Methods MS patients’ sera were screened by a protein macroarray derived from human fetal brain cDNA library (hEX1). Sera of 90 consecutive relapsing remitting MS (RRMS) patients an...

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Bibliographic Details
Published in:Inflammation research 2012-09, Vol.61 (9), p.927-930
Main Authors: Erdağ, Ece, Tüzün, Erdem, Uğurel, Elif, Çavuş, Filiz, Şehitoğlu, Elçin, Giriş, Murat, Vural, Burçak, Eraksoy, Mefküre, Akman-Demir, Gülşen
Format: Article
Language:English
Subjects:
Adult
Allergology
Antibodies - blood
Antibodies - immunology
Behcet Syndrome - blood
Behcet Syndrome - immunology
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Dermatology
DNA-Binding Proteins - immunology
Female
Guanine Nucleotide Exchange Factors - immunology
Humans
Immunology
Male
Meningoencephalitis - blood
Meningoencephalitis - immunology
Minor Histocompatibility Antigens
Multiple Sclerosis, Relapsing-Remitting - blood
Multiple Sclerosis, Relapsing-Remitting - immunology
Neurology
Nuclear Proteins - immunology
Pharmacology/Toxicology
Recurrence
Rheumatology
Short Communication
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Summary:Objective To identify an antibody biomarker for multiple sclerosis (MS) that can be used as a predictor of MS relapses. Methods MS patients’ sera were screened by a protein macroarray derived from human fetal brain cDNA library (hEX1). Sera of 90 consecutive relapsing remitting MS (RRMS) patients and age-matched 145 Behçet’s disease (BD) patients, 40 infectious meningoencephalitis patients, and 70 healthy controls were screened by ELISA for serum antibodies against the selected clone. Results Sequencing of the clone with the highest signal intensity revealed switch-associated protein 70 (SWAP70) as a potential target autoantigen in RRMS. ELISA studies showed high-titer SWAP70-antibodies in 21 (23.3 %) RRMS and 7 (4.8 %) BD patients. SWAP70 antibodies were more likely to be found positive in sera obtained during or shortly after a relapse. Conclusion Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in MS relapse pathogenesis. Whether serum SWAP70 antibody detection may be utilized as an MS relapse predictor should be tested in prospective studies.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-012-0488-9