De Novo Synthesis of 1,4-Dihydropyridines and Pyridines

An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society 2012-06, Vol.134 (22), p.9078-9081
Main Authors: Gati, Wafa, Rammah, Mohamed M, Rammah, Mohamed B, Couty, François, Evano, Gwilherm
Format: Article
Language:English
Subjects:
Molecular Structure
Pyridines - chemical synthesis
Pyridines - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja303002a