Metabotropic glutamate subtype 7 and 8 receptors oppositely modulate cardiac nociception in the rat nucleus tractus solitarius

Highlights ► Group III mGluRs modulate cardiac-somatic reflex evoked by pericardiac capsaicin. ► Activation of mGluR7 depresses cardiac-somatic reflex. ► Activation of mGluR8 facilitates cardiac-somatic reflex. ► Opposite roles of mGluR7 and 8 may be related to different sites of action.

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Bibliographic Details
Published in:Neuroscience 2012-09, Vol.220, p.322-329
Main Authors: Liu, X.H, Han, M, Zhu, J.X, Sun, N, Tang, J.S, Huo, F.Q, Li, J, Xu, F.Y, Du, J.Q
Format: Article
Language:English
Subjects:
Afferent Pathways - physiology
Animals
Biological and medical sciences
cardiac nociception
cardiac-somatic reflex
descending modulation
Fundamental and applied biological sciences. Psychology
Heart - innervation
Male
mGluR III
Neurology
Nociception - physiology
nucleus tractus solitarius
Pain, Referred - metabolism
rat
Rats
Rats, Sprague-Dawley
Receptors, Metabotropic Glutamate - metabolism
Solitary Nucleus - metabolism
Thorax
Vagus Nerve - physiology
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Group III mGluRs modulate cardiac-somatic reflex evoked by pericardiac capsaicin. ► Activation of mGluR7 depresses cardiac-somatic reflex. ► Activation of mGluR8 facilitates cardiac-somatic reflex. ► Opposite roles of mGluR7 and 8 may be related to different sites of action.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.05.024