Nortriterpene Glycosides of the Sarasinoside Class from the Sponge Lipastrotethya sp

Five new nortriterpene glycosides, along with eight known compounds of the sarasinoside class, were isolated from the tropical sponge Lipastrotethya sp. collected from Chuuk, Micronesia. The structures of these new compounds, designated as sarasinosides N–R (9–13), were determined by combined spectr...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2012-07, Vol.75 (7), p.1365-1372
Main Authors: Lee, Jung-Ho, Jeon, Ju-eun, Lee, Yeon-Ju, Lee, Hyi-Seung, Sim, Chung J, Oh, Ki-Bong, Shin, Jongheon
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Drug Screening Assays, Antitumor
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Humans
K562 Cells
Micronesia
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera - chemistry
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:Five new nortriterpene glycosides, along with eight known compounds of the sarasinoside class, were isolated from the tropical sponge Lipastrotethya sp. collected from Chuuk, Micronesia. The structures of these new compounds, designated as sarasinosides N–R (9–13), were determined by combined spectroscopic and chemical methods. The aglycone portions of 10–13 were found to be unprecedented among nortriterpeneoids on the basis of extensive NMR analyses. Several of these compounds exhibited cytotoxicity against A549 and K562 cell lines as well as weak inhibitory activity against Na+/K+-ATPase.
ISSN:0163-3864
1520-6025
DOI:10.1021/np300297d