Elevated human epididymis protein 4 concentrations in chronic kidney disease

Background Human epididymis protein 4 (HE4) has recently become an available tumour biomarker for detecting ovarian cancer along with the standard cancer antigen 125 (CA125). However, it is unknown if the levels of HE4 and CA125 may be altered in subjects who have impaired renal function with no ova...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2012-07, Vol.49 (4), p.377-380
Main Authors: Nagy, Béla, Krasznai, Zoárd T, Balla, Heidi, Csobán, Mária, Antal-Szalmás, Péter, Hernádi, Zoltán, Kappelmayer, János
Format: Article
Language:English
Subjects:
Epididymis - metabolism
Humans
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - physiopathology
Kidney Function Tests
Male
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Summary:Background Human epididymis protein 4 (HE4) has recently become an available tumour biomarker for detecting ovarian cancer along with the standard cancer antigen 125 (CA125). However, it is unknown if the levels of HE4 and CA125 may be altered in subjects who have impaired renal function with no ovarian disorders. Methods In 113 female patients at different stages of chronic kidney disease (CKD) with no ovarian and lung cancer and 68 subjects with normal renal and ovarian function, HE4 and CA125 concentrations were analysed by using chemiluminescent microparticle immunoassay (Architect®, Abbott) and electrochemiluminescent immunoassay (Modular E170®, Roche), respectively. Renal function was evaluated by measuring serum creatinine and urea concentrations (Cobas Integra-800®, Roche). Estimated glomerular filtration rate (eGFR in mL/min/1.73 m2) was calculated by the 4v-MDRD formula. Results Significantly increased HE4 concentrations (P < 0.0001) were found in individuals with differently decreased eGFR values (
ISSN:0004-5632
1758-1001
DOI:10.1258/acb.2011.011258