Meta-analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon-α and ribavirin

Summary Background Interleukin (IL) 28B single nucleotide polymorphisms can predict sustained virological response (SVR) in hepatitis C virus (HCV) patients following pegylated interferon‐alpha (PEG IFN‐α) and ribavirin treatment. Aim To design a meta‐analysis to determine IL28B genotypes', rs1...

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Published in:Alimentary pharmacology & therapeutics 2012-07, Vol.36 (2), p.91-103
Main Authors: Chen, Y., Xu, H.-X., Wang, L.-J., Liu, X.-X., Mahato, R. I., Zhao, Y.-R.
Format: Article
Language:English
Subjects:
alpha -Interferon
Antiviral Agents - therapeutic use
Biological and medical sciences
Digestive system
Drug Therapy, Combination
Ethnic groups
Gastroenterology. Liver. Pancreas. Abdomen
Gene polymorphism
Genotype
Hepacivirus - drug effects
Hepacivirus - genetics
Hepatitis C - drug therapy
Hepatitis C - genetics
Hepatitis C virus
Humans
Infection
Infectious diseases
Interferon alpha-2
Interferon-alpha - therapeutic use
Interferons
Interleukins
Interleukins - genetics
Medical sciences
Pharmacology. Drug treatments
Polyethylene glycol
Polyethylene Glycols - therapeutic use
Polymorphism, Single Nucleotide
Predictive Value of Tests
Recombinant Proteins - therapeutic use
Reviews
Ribavirin
Ribavirin - therapeutic use
Single-nucleotide polymorphism
Treatment Outcome
Viral diseases
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Summary:Summary Background Interleukin (IL) 28B single nucleotide polymorphisms can predict sustained virological response (SVR) in hepatitis C virus (HCV) patients following pegylated interferon‐alpha (PEG IFN‐α) and ribavirin treatment. Aim To design a meta‐analysis to determine IL28B genotypes', rs12979860 CC and rs8099917 TT, correlation with SVR in PEG IFN‐α/ribavirin‐treated HCV patients. Methods Meta‐analysis was performed in 17 studies of rs12979860 CC vs. CT/TT and 17 of rs8099917 TT vs. TG/GG. Odds ratios (OR) and confidence intervals (95% CI) were calculated by fixed‐ or random‐effects models. Heterogeneity, sensitivity analysis and publication bias were also assessed. Results Of 4252 Asian, Caucasian and African HCV patients analysed for rs12979860, SVR was more frequent in CC (vs. CT/TT; OR = 4.76, 95% CI: 3.15–7.20). Moreover, CC was associated with SVR for HCV genotype‐1 or ‐4 infections (ORgenotype 1 = 5.52, 95% CI: 3.74–8.15; ORgenotype 4 = 8.11, 95% CI: 4.13–15.93), regardless of ethnicity. Of 4549 Caucasian and Asian HCV patients analysed for rs8099917, SVR was more frequent in TT (vs. TG/GG; OR = 3.31, 95% CI: 2.39–4.59). Moreover, TT was associated with SVR for HCV‐1 (ORgenotype 1 = 4.28, 95% CI: 2.87–6.38). Rs8099917 TT predictive value was stronger in Asians (ORAsians = 8.09, 95% CI: 5.63–11.61; ORCaucasians = 3.00, 95% CI: 2.03–4.45). Ethnicity stratification revealed that rs8099917 TT had slight predictive value in Asian HCV‐2/3 patients (OR = 1.99, 95% CI: 1.09–3.62). Conclusions IL28B rs12979860 CC and rs8099917 TT are strong SVR predictors for PEG IFN‐α/ribavirin‐treated HCV‐1 patients, regardless of ethnicity. In HCV‐2/3, rs12979860 CC has no SVR predictive value, but rs8099917 TT was slightly associated with SVR in Asians.
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2012.05131.x