Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release

Abstract A new type of redox/pH dual stimuli-responsive poly(methacrylic acid) (PMAA)-based nanohydrogels was prepared from methacrylic acid and N,N -bis(acryloyl)cystamine crosslinker via distillation-precipitation polymerization. The nanohydrogels could be easily degraded into individual linear sh...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials 2012-09, Vol.33 (27), p.6570-6579
Main Authors: Pan, Yuan-Jia, Chen, Yuan-Yuan, Wang, Dong-Rui, Wei, Chuan, Guo, Jia, Lu, Da-Ru, Chu, Chih-Chang, Wang, Chang-Chun
Format: Article
Language:English
Subjects:
Advanced Basic Science
Biocompatible Materials - chemistry
Biodegradable
Biodegradation, Environmental
Cell Line, Tumor
Cell Survival - drug effects
Cross-Linking Reagents - chemistry
Delayed-Action Preparations
Dentistry
Distillation-precipitation polymerization
Disulfides - chemistry
Dithiothreitol - pharmacology
Doxorubicin - chemistry
Doxorubicin - pharmacology
Drug delivery
Glutathione - pharmacology
HEK293 Cells
Humans
Hydrogels - chemistry
Hydrogen-Ion Concentration - drug effects
Microscopy, Fluorescence
Microscopy, Phase-Contrast
Nanohydrogel
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Oxidation-Reduction - drug effects
pH-responsive
Polymethacrylic Acids - chemistry
Redox-responsive
Spectroscopy, Fourier Transform Infrared
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A new type of redox/pH dual stimuli-responsive poly(methacrylic acid) (PMAA)-based nanohydrogels was prepared from methacrylic acid and N,N -bis(acryloyl)cystamine crosslinker via distillation-precipitation polymerization. The nanohydrogels could be easily degraded into individual linear short chains (Mn  ≈ 1200, Mw /Mn  
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2012.05.062