Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man

Abstract Human herpes simplex virus infections are very common and represent significant morbidity in the immunocompromised host. Patients with acyclovir resistant strains of HSV based on viral thymidine kinase gene mutations need alternative therapeutic approaches. Leflunomide has been shown to pos...

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Bibliographic Details

Published in:	Journal of clinical virology 2012-07, Vol.54 (3), p.276-278
Main Authors:	Henao-Martínez, Andrés F, Weinberg, Adriana, Waldman, W. James, Levi, Marilyn E
Format:	Article
Language:	eng
Subjects:	acyclovir Acyclovir - pharmacology Adult Allergy and Immunology Antiviral activity Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Biological and medical sciences Drug Resistance, Viral Fundamental and applied biological sciences. Psychology Herpes Genitalis - drug therapy Herpes Genitalis - virology Herpes simplex virus Herpes simplex virus 2 Herpesvirus 2, Human - isolation & purification HIV Infections - complications Human immunodeficiency virus Human viral diseases Humans Immunocompromised hosts Infection Infectious Disease Infectious diseases Isoxazoles - administration & dosage Leflunomide Male Medical sciences Microbiology Miscellaneous Morbidity Point mutation Proctitis Proctitis - drug therapy Proctitis - virology Side effects Thymidine kinase Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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