Monoclonal gammopathy related to Sjögren syndrome: A key marker of disease prognosis and outcomes

Abstract Objective To analyze the monoclonal expression of SS through the detection of serum monoclonal immunoglobulins (mIgs) in a large series of patients with Sjögren syndrome (SS), focusing on the etiology, characterization and evolution of the monoclonal band and the association with SS clinica...

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Bibliographic Details
Published in:Journal of autoimmunity 2012-08, Vol.39 (1), p.43-48
Main Authors: Brito-Zerón, Pilar, Retamozo, Soledad, Gandía, Myriam, Akasbi, Miriam, Pérez-De-Lis, Marta, Diaz-Lagares, Candido, Bosch, Xavier, Bové, Albert, Pérez-Alvarez, Roberto, Soto-Cárdenas, María-José, Sisó, Antoni, Ramos-Casals, Manuel
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies, Monoclonal - blood
Biological and medical sciences
Biomarkers - blood
Cryoglobulinemia
Cryoglobulins
Etiology
Evolution
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hematologic and hematopoietic diseases
Hepatitis C - complications
Hepatitis C virus
Humans
Hypergammaglobulinemia
Hypocomplementemia
Immunodeficiencies. Immunoglobulinopathies
Immunoelectrophoresis
Immunoglobulin A
Immunoglobulin A - blood
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin kappa-Chains - blood
Immunoglobulin lambda-Chains - blood
Immunoglobulin M
Immunoglobulin M - blood
Immunoglobulinopathies
Immunopathology
Infection
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Light chains
Lymphoma
Male
Medical sciences
Middle Aged
Monoclonal gammopathy
Mortality
Neoplasia
Paraproteinemias
Primary Sjögren syndrome
Prognosis
Rheumatoid factor
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sjogren's syndrome
Sjogren's Syndrome - immunology
Survival
Treatment Outcome
Vasculitis
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Summary:Abstract Objective To analyze the monoclonal expression of SS through the detection of serum monoclonal immunoglobulins (mIgs) in a large series of patients with Sjögren syndrome (SS), focusing on the etiology, characterization and evolution of the monoclonal band and the association with SS clinical expression and outcomes. Methods Serum immunoelectrophoresis (IE) was performed to 408 consecutive patients who were evaluated by our unit between 1992 and 2011: 221 patients who fulfilled the 2002 American–European criteria for primary SS, 122 primary SS patients who fulfilled exclusively the 1993 European criteria and 65 patients with SS-associated hepatitis C virus infection. IE was performed at diagnosis and every year during the follow-up. Results Of the 221 patients with primary SS, 48 (22%) had monoclonal gammopathy. In the control groups, the prevalence was 16% in patients with SS who fulfilled the 1993 criteria ( p  > 0.05) and 52% in SS-HCV patients ( p  
ISSN:0896-8411
1095-9157
DOI:10.1016/j.jaut.2012.01.010