Evaluation of panoramic radiomorphometric indices related to low bone density in sickle cell disease

Summary In sickle cell disease, erythroid hyperplasia causes trabecular destruction leading to low bone density. This condition could be suspected by the radiomorphometric indices and your diagnosis becomes relevant in a multidisciplinary context of health care for sickle cell subjects, providing pr...

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Bibliographic Details
Published in:Osteoporosis international 2012-07, Vol.23 (7), p.2037-2042
Main Authors: Neves, F. S., Oliveira, L. S. A. F., Torres, M. G. G., Toralles, M. B. P., da Silva, M. C. B. O., Campos, M. I. G., Campos, P. S. F., Crusoé-Rebello, I.
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Anemia, Sickle Cell - complications
Bone (trabecular)
Bone density
Data processing
Endocrinology
Female
Humans
Hyperplasia
Male
Mandible
Mandible - diagnostic imaging
Medicine
Medicine & Public Health
Middle Aged
Original Article
Orthopedics
Osteoporosis
Osteoporosis - diagnostic imaging
Osteoporosis - etiology
Radiography
Radiography, Panoramic - methods
Rheumatology
Risk factors
Sickle cell disease
Statistical analysis
Young Adult
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Summary:Summary In sickle cell disease, erythroid hyperplasia causes trabecular destruction leading to low bone density. This condition could be suspected by the radiomorphometric indices and your diagnosis becomes relevant in a multidisciplinary context of health care for sickle cell subjects, providing prognostics and contributing to determine adequate therapeutic and preventive actions. Introduction The aim of this study was to assess the risk of low bone density in subjects with sickle cell disease (SCD) through analysis of panoramic radiographic exams by radiomorphometric indices. Methods Seventy-eight Brazilian subjects with SCD took part in this study and were subdivided into four groups: (I) 31 SCD subjects aged under 40 years; (II) 13 SCD subjects aged 40 years or more; (III) 12 normal subjects aged under 40 years; and (IV) 22 normal subjects aged 40 years or more. In the panoramic radiographs, the mandibular cortical index (MCI) classification, increased spacing of the trabecular bone, panoramic mandibular index (PMI), and mental index (MI) were evaluated. Exact Fisher's test was used to compare age between the different groups. Descriptive analysis of the data was performed to evaluate the simple visual estimation of low bone density (increased bone trabecular space and MCI), and a one-way analysis of variance (Bonferroni criteria) was used to compare the means of the quantitative indices (PMI and MI). The significance level was p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-011-1810-z