Neuroendocrine Changes and Natriuresis in Response to Social Stress in Rats

Sympathetic activation is detected by the tachycardic, hypertensive and hyperthermic responses during social conflicts in rodents and primates. Sympathetic nervous system activation promoting sodium retention has long been recognized to play a significant role in the development and maintenance of s...

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Bibliographic Details
Published in:Stress and health 2012-08, Vol.28 (3), p.179-185
Main Authors: Niebylski, A., Boccolini, A., Bensi, N., Binotti, S., Hansen, C., Yaciuk, R., Gauna, H.
Format: Article
Language:English
Subjects:
aldosterone
Aldosterone - blood
Analysis of Variance
Animals
Arterial hypertension. Arterial hypotension
Behavior, Animal - physiology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
catecholamines
Catecholamines - urine
Chronic Disease
Corticosterone - blood
Disease Models, Animal
Endocrinology
Female
Hormones
Housing, Animal
Hypertension
Hypertension - metabolism
Kidney - physiopathology
Male
Medical sciences
natriuresis
Natriuresis - physiology
Nervous system
Neurosecretory Systems - metabolism
Neurosecretory Systems - physiopathology
Primates
Rats
Rats, Wistar
Rodents
social stress
Sodium
Sodium, Dietary - administration & dosage
Sodium, Dietary - metabolism
Stress
Stress, Psychological - blood
Stress, Psychological - metabolism
Stress, Psychological - urine
Sympathetic Nervous System - physiopathology
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Summary:Sympathetic activation is detected by the tachycardic, hypertensive and hyperthermic responses during social conflicts in rodents and primates. Sympathetic nervous system activation promoting sodium retention has long been recognized to play a significant role in the development and maintenance of salt‐sensitive hypertension. The objective was to investigate neuroendocrine activation and renal sodium excretion in response to chronic social stress. Male Wistar rats were subjected to social stress in accordance with the resident–intruder paradigm. Intruder rats were subjected to social confrontation once daily for 6 days. After the last confrontation, plasma corticosterone and urinary catecholamines were determined to assess the neuroendocrine activation. Plasma aldosterone, plasma and urinary creatinine, Na+, K+ and urinary volume were also measured. Chronic social stress increased the urinary norepinephrine, dopamine and plasma corticosterone levels, with no changes in epinephrine levels. On the other hand, high plasma aldosterone levels and low urinary sodium excretion without differences in creatinine clearance were observed. In conclusion, social stress had a strong antinatriuretic effect, which is coincident with noradrenergic and corticoadrenal activation and an increase in plasma aldosterone levels. Activation of these factors may promote sodium retention, which has long been recognized to play a significant role in the development and maintenance of hypertension. Copyright © 2011 John Wiley & Sons, Ltd.
ISSN:1532-3005
1532-2998
DOI:10.1002/smi.1411