Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes

Summary Background & aims Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. Ob...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2012-08, Vol.31 (4), p.520-525
Main Authors: Petit, J.M, Guiu, B, Duvillard, L, Jooste, V, Brindisi, M.C, Athias, A, Bouillet, B, Habchi, M, Cottet, V, Gambert, P, Hillon, P, Cercueil, J.P, Verges, B
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Dietary Fats - administration & dosage
Dietary Supplements
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Erythrocytes - chemistry
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty acid composition
Fatty Acids, Monounsaturated - analysis
Fatty Acids, Monounsaturated - metabolism
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-6 - administration & dosage
Fatty Acids, Omega-6 - blood
Fatty Liver - complications
Fatty Liver - physiopathology
Fatty Liver - prevention & control
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Humans
Male
Medical sciences
Middle Aged
Non-alcoholic Fatty Liver Disease
Palmitic Acid - analysis
Palmitic Acid - metabolism
Prevalence
Prospective Studies
PUFA
Steatosis
Triglycerides - blood
Type 2 diabetes
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Summary Background & aims Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. Objective In this study, we set out to determine whether liver fat content (LFC), was associated with red blood cell fatty acid (RBC-FA) composition in people with type 2 diabetes. Design, settings, and participants One hundred and sixty-two type 2 diabetic patients were included in this study. LFC was measured using1 H-MR Spectroscopy. RBC-FA composition was measured by gas chromatography. Results One hundred and nine (67.2%) patients had steatosis. Patients with steatosis had a higher BMI ( p = 0.0005), and higher plasma triglyceride levels ( p = 0.009) than did patients without steatosis. We report a significant association between palmitic acid (16:0), palmitoleic acid (16:1n-7) concentrations and ratio of monounsaturated to saturated fatty acid (palmitoleic acid to palmitic acid) and higher liver fat content. Total polyunsaturated fatty acid (PUFA), homo-gamma-linolenic acid (20:3n-6), docosahexaenoic acid (22:6n-3), and arachidonic acid (20:4 n-6) were associated with lower LFC. Conclusions Our data showed that an increased erythrocytes long-chain n-3 and n-6 fatty acids was associated with a lower prevalence of steatosis in patients with type 2 diabetes. These results suggest that n-3 and n-6 fatty acids supplementation could be a promising treatment for NAFLD in patients with type 2 diabetes.
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2011.12.007