Ultrasound-induced release of GDNF from lipid coated microbubbles injected into striatum reduces hypoxic–ischemic injury in neonatal rats

Highlights ► We prepared ultrasound-induced dissolution of lipid-coated GDNF microbubbles. ► The microbubbles were injected into the rat brains with hypoxic–ischemic injury. ► Microbubbles reduced infarct volume and improved neurological outcomes. ► Microbubbles reduced nitric oxide production and t...

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Bibliographic Details
Published in:Brain research bulletin 2012-08, Vol.88 (5), p.495-500
Main Authors: Wang, Xiaoying, Guo, Shenglan, Lu, Shuangquan, Zhou, Jianmin, Li, Jingcai, Xia, Sili
Format: Article
Language:English
Subjects:
Animal models
Animals
Animals, Newborn
Corpus Striatum - drug effects
Corpus Striatum - pathology
Corpus Striatum - secretion
Drug Delivery Systems - methods
Female
GDNF-containing microbubbles
Glial Cell Line-Derived Neurotrophic Factor - administration & dosage
Glial Cell Line-Derived Neurotrophic Factor - secretion
Glial line-derived neurotrophic factor
Hypoxia-Ischemia, Brain - metabolism
Hypoxia-Ischemia, Brain - pathology
Hypoxia-Ischemia, Brain - prevention & control
Hypoxia–ischemia
Inducible nitric oxide synthase
Injections, Intraventricular
Lipids - administration & dosage
Microbubbles
Neurology
Nitric oxide
Rats
Rats, Wistar
Tumor necrosis factor-alpha
Ultrasonics - methods
Ultrasound
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Summary:Highlights ► We prepared ultrasound-induced dissolution of lipid-coated GDNF microbubbles. ► The microbubbles were injected into the rat brains with hypoxic–ischemic injury. ► Microbubbles reduced infarct volume and improved neurological outcomes. ► Microbubbles reduced nitric oxide production and the activation of caspase-3. ► Microbubbles treatment reduced iNOS levels and TNF-α expression.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2012.05.001