Effect of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Antagonists in Atherosclerosis Prevention

Atherosclerosis is a highly complex biological process that has become the scourge of modern civilization. Endothelial dysfunction is the first step in the development of atherosclerosis. The renin-angiotensin-aldosterone system (RAAS) plays an important role in the development of endothelial dysfun...

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Bibliographic Details
Published in:Current cardiology reports 2012-08, Vol.14 (4), p.433-442
Main Authors: Patarroyo Aponte, Maria M., Francis, Gary S.
Format: Article
Language:English
Subjects:
Angiotensin Receptor Antagonists - pharmacology
Angiotensin Receptor Antagonists - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Atherosclerosis - physiopathology
Atherosclerosis - prevention & control
Cardiology
Endothelium, Vascular - physiopathology
Humans
Ischemic Heart Disease (S Brener
Medicine
Medicine & Public Health
Renin-Angiotensin System - drug effects
Renin-Angiotensin System - physiology
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Summary:Atherosclerosis is a highly complex biological process that has become the scourge of modern civilization. Endothelial dysfunction is the first step in the development of atherosclerosis. The renin-angiotensin-aldosterone system (RAAS) plays an important role in the development of endothelial dysfunction and atherosclerosis. Several studies have shown that in vitro blockade of the RAAS is associated with improvement in markers of endothelial dysfunction and inflammation. Many clinical trials have demonstrated a clear benefit of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) manifested by a reduction of cardiovascular events. These findings suggest that ACEIs and ARBs can play an important role in prevention of atherosclerosis and in the delay of its progression. In this review we focus on the importance of RAAS blockade to prevent or delay progression of atherosclerosis and its impact on reduction of cardiovascular events.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-012-0275-9