Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM®)

Summary We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group recei...

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Bibliographic Details
Published in:Anaesthesia 2012-08, Vol.67 (8), p.862-869
Main Authors: Na, H. S., Chung, Y. H., Hwang, J. W., Do, S. H.
Format: Article
Language:English
Subjects:
Adult
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Coagulation - drug effects
Coagulation
Double-Blind Method
Gynecology
Humans
Magnesium
Magnesium Sulfate - pharmacology
Medical sciences
Postoperative Complications - prevention & control
Postoperative period
Surgery
Thrombelastography - methods
Thrombophilia - prevention & control
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Summary:Summary We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate (50 mg.kg−1 followed by continuous infusion of 15 mg.kg−1.h−1), whereas the control group received the same volume of isotonic saline according to the same methods. Mean (SD) postoperative serum magnesium levels were 1.58 (0.17) mmol.l−1 in the magnesium group compared with 0.98 (0.06) mmol.l−1 in the control group (p 
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.2012.07149.x