The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice

Spiranthera odoratissima A. St. Hil. (manacá) is used in folk medicine to treat renal and hepatic diseases, stomachache, headaches and rheumatism. A central nervous system (CNS) depressant effect of the hexane fraction from the ethanolic extract of this plant has been described. β-caryophyllene, the...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2012-08, Vol.38 (2), p.276-284
Main Authors: Galdino, Pablinny Moreira, Nascimento, Marcus Vinícius Mariano, Florentino, Iziara Ferreira, Lino, Roberta Campos, Fajemiroye, James Oluwagbamigbe, Chaibub, Beatriz Abdallah, de Paula, José Realino, de Lima, Thereza Christina Monteiro, Costa, Elson Alves
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - pharmacology
Anti-Anxiety Agents - therapeutic use
Anxiety - drug therapy
Anxiolytic‐like effect
Behavior, Animal - drug effects
Biological and medical sciences
Flumazenil
Male
Medical sciences
Mice
Motor Activity - drug effects
NAN-190
Neuropharmacology
Oils, Volatile - pharmacology
Oils, Volatile - therapeutic use
Pentobarbital - pharmacology
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rotarod Performance Test
Rutaceae
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Sleep - drug effects
Spiranthera odoratissima
β-caryophyllene
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Summary:Spiranthera odoratissima A. St. Hil. (manacá) is used in folk medicine to treat renal and hepatic diseases, stomachache, headaches and rheumatism. A central nervous system (CNS) depressant effect of the hexane fraction from the ethanolic extract of this plant has been described. β-caryophyllene, the main component of this essential oil, is a sesquiterpene compound with anti-inflammatory properties that has been found in essential oils derived from several medicinal plants. This work is aimed to evaluate the pharmacological activity of the essential oil obtained from S. odoratissima leaves (EO) and its major component on the murine CNS; we aimed to evaluate a possible anxiolytic-like effect and the underlying mechanisms involved. In an open field test, EO (500mg/kg) and β-caryophyllene (50, 100 and 200mg/kg) increased the crossing frequency (P
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2012.04.012