Bone Engineering by Biomimetic Injectable Hydrogel

Osteoporosis is a multifactorial bone disease characterized by low bone mineral density (BMD) and deterioration of micro-architecture of cancellous bone leading to bone fragility and risk of fractures. In the current work, a novel tissue engineering strategy was experimented to enhance bone architec...

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Bibliographic Details
Published in:Molecular Crystals and Liquid Crystals 2012-04, Vol.555 (1), p.177-188
Main Authors: Nageeb, Mohamad, Nouh, Samir R., Bergman, Kristoffer, Nagy, Naglaa B., Khamis, Dalia, Kisiel, Marta, Engstrand, Thomas, Hilborn, Jöns, Marei, Mona K.
Format: Article
Language:English
Subjects:
Architecture
Bioengineering
Biomedical materials
Bone density
Bone engineering
Bones
Chemistry
Chemistry with specialization in Polymer Chemistry
Density
Fractures
hyaluronic acid
Hydrogels
Hydroxyapatite
injectable hydrogels
Kemi
Kemi med inriktning mot polymerkemi
Nanostructure
NATURAL SCIENCES
NATURVETENSKAP
Organic chemistry
Organisk kemi
osteoinduction
Osteoporosis
Polymer chemistry
Polymerkemi
Rabbits
Risk
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Summary:Osteoporosis is a multifactorial bone disease characterized by low bone mineral density (BMD) and deterioration of micro-architecture of cancellous bone leading to bone fragility and risk of fractures. In the current work, a novel tissue engineering strategy was experimented to enhance bone architecture in the risk areas via local injection of a biomimetic/osteoinductive injectable hyaluronan based hydrogel loaded with nano-hydroxyapatite crystals (Hya/HA) with/without bone morphogenetic protein (BMP-2), in distal femur of normal and ovariectomized New Zealand white rabbits. Our results revealed the osteoinductive effect of the Hya/HA composite that enhanced bone density and architecture of the rabbit distal femur.
ISSN:1542-1406
1563-5287
1527-1943
DOI:10.1080/15421406.2012.635530