Neoplastic spindle cells in nasopharyngeal carcinoma show features of epithelial-mesenchymal transition

Luo W‐R, Chen X‐Y, Li S‐Y, Wu A‐B & Yao K‐T 
(2012) Histopathology 61, 113–122 Neoplastic spindle cells in nasopharyngeal carcinoma show features of epithelial–mesenchymal transition Aim:  To investigate whether the neoplastic spindle cells in nasopharyngeal carcinoma (NPC) are associated with t...

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Bibliographic Details
Published in:Histopathology 2012-07, Vol.61 (1), p.113-122
Main Authors: Luo, Wei-Ren, Chen, Xiao-Yi, Li, Si-Yi, Wu, Ai-Bing, Yao, Kai-Tai
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
beta Catenin - metabolism
Biological and medical sciences
Biomarkers, Tumor - metabolism
Cadherins - metabolism
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Disease Progression
Epithelial-Mesenchymal Transition
Female
Fibroblasts - metabolism
Fibroblasts - pathology
Fibronectins - metabolism
Humans
immunohistochemistry
Immunohistochemistry - methods
Investigative techniques, diagnostic techniques (general aspects)
Isoenzymes - metabolism
Keratins - metabolism
Male
Medical sciences
Middle Aged
nasopharyngeal carcinoma
Nasopharyngeal Neoplasms - metabolism
Nasopharyngeal Neoplasms - pathology
Neoplasm Invasiveness - pathology
Otorhinolaryngology. Stomatology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Retinal Dehydrogenase - metabolism
Snail Family Transcription Factors
spindle cell
Transcription Factors - metabolism
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Vimentin - metabolism
Young Adult
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Summary:Luo W‐R, Chen X‐Y, Li S‐Y, Wu A‐B & Yao K‐T 
(2012) Histopathology 61, 113–122 Neoplastic spindle cells in nasopharyngeal carcinoma show features of epithelial–mesenchymal transition Aim:  To investigate whether the neoplastic spindle cells in nasopharyngeal carcinoma (NPC) are associated with the process of epithelial–mesenchymal transition (EMT). Methods and results:  We used immunohistochemistry to analyse the expression of cytokeratin, E‐cadherin, β‐catenin, vimentin, fibronectin, Snail1, Slug and aldehyde dehydrogenase 1 (ALDH1) in 115 cases of NPC in which there were neoplastic spindle cells; in 47 cases a neoplastic squamous cell component was also present. There was no significant difference in the expression of cytokeratin observed in the neoplastic spindle cells (P = 0.644), compared to the squamous component whereas E‐cadherin expression was reduced. By contrast, the expression of β‐catenin, vimentin, fibronectin, Snail1, Slug and ALDH1 was up‐regulated in the spindle cells (all P = 0.000). Furthermore, E‐cadherin expression was associated negatively with β‐catenin (P < 0.001), vimentin (P < 0.001), fibronectin (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2012.04205.x