Community-acquired Staphylococcus aureus necrotizing pneumonia secreting Panton-Valentine leukocidin in an infant

Staphylococcus aureus (SA) necrotizing pneumonia secreting Panton-Valentine leukocidin (PVL) has a high mortality rate, approximately 50% according to recent data, mainly in children and young adults. Recently, 2 cases of the disease have been reported in newborn twins with a good outcome. We report...

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Bibliographic Details
Published in:Archives de pédiatrie : organe officiel de la Société française de pédiatrie 2012-07, Vol.19 (7), p.718-721
Main Authors: Millet, A, Desrumaux, A, Gayot, A, Tristan, A, Emeriaud, G, Debillon, T, Wroblewski, I
Format: Article
Language:fre
Subjects:
Bacterial Toxins
Community-Acquired Infections - metabolism
Community-Acquired Infections - pathology
Exotoxins - secretion
Humans
Infant
Leukocidins - secretion
Male
Necrosis
Pneumonia, Staphylococcal - metabolism
Pneumonia, Staphylococcal - pathology
Staphylococcus aureus
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Summary:Staphylococcus aureus (SA) necrotizing pneumonia secreting Panton-Valentine leukocidin (PVL) has a high mortality rate, approximately 50% according to recent data, mainly in children and young adults. Recently, 2 cases of the disease have been reported in newborn twins with a good outcome. We report a third case of community-acquired necrotizing pneumonia due to SA sensitive to methicillin (SASM) secreting Panton-Valentine leukocidin (PVL) in an infant, initially paucisymptomatic, in the context of familial furunculosis, with a fatal outcome. Cases of necrotizing pneumonia in this age group are emerging, and extensive information for clinicians is needed due to the high mortality rate of the disease.
ISSN:1769-664X
DOI:10.1016/j.arcped.2012.04.027