Adenocarcinomas of the Esophagogastric Junction Are More Likely to Respond to Preoperative Chemotherapy than Distal Gastric Cancer

Background Preoperative chemotherapy has been shown to improve outcome of patients with adenocarcinoma of the esophagogastric junction (AEG) and gastric cancer (GC), and histopathologic response has been identified as an independent prognostic parameter in these patients. A recent meta-analysis has...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2012-07, Vol.19 (7), p.2108-2118
Main Authors: Reim, Daniel, Gertler, Ralf, Novotny, Alexander, Becker, Karen, Büschenfelde, Christian Meyer zum, Ebert, Matthias, Dobritz, Martin, Langer, Rupert, Hoefler, Heinz, Friess, Helmut, Schumacher, Christoph
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - mortality
Adenocarcinoma - surgery
Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Combined Modality Therapy
Esophageal Neoplasms - drug therapy
Esophageal Neoplasms - mortality
Esophageal Neoplasms - surgery
Esophagogastric Junction - pathology
Female
Follow-Up Studies
Gastrointestinal Oncology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - surgery
Neoplasm Staging
Oncology
Preoperative Care
Prognosis
Prospective Studies
Retrospective Studies
Risk Factors
Stomach Neoplasms - drug therapy
Stomach Neoplasms - mortality
Stomach Neoplasms - surgery
Surgery
Surgical Oncology
Survival Rate
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Preoperative chemotherapy has been shown to improve outcome of patients with adenocarcinoma of the esophagogastric junction (AEG) and gastric cancer (GC), and histopathologic response has been identified as an independent prognostic parameter in these patients. A recent meta-analysis has identified patients with AEG as benefiting more from preoperative chemotherapy than patients with GC. The aim of this retrospective analysis was to prove these findings in an experienced single-center large patient cohort because there are currently no recruiting prospective clinical trials. Methods In a single center, 551 patients underwent preoperative platin-based chemotherapy followed by oncologic surgery for locally advanced AEG and GC. Pretherapeutic clinical parameters were correlated with histopathologic response to preoperative chemotherapy. Results Histopathologic response (
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-011-2147-8