Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women

Soy isoflavones have antiestrogenic and anticancer properties but also possess estrogen-like properties, which has raised concern about soy food consumption among breast cancer survivors. We prospectively evaluated the association between postdiagnosis soy food consumption and breast cancer outcomes...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of clinical nutrition 2012-07, Vol.96 (1), p.123-132
Main Authors: NECHUTA, Sarah J, CAAN, Bette J, XIAO OU SHU, CHEN, Wendy Y, WEI LU, ZHI CHEN, KWAN, Marilyn L, FLATT, Shirley W, YING ZHENG, WEI ZHENG, PIERCE, John P
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Breast cancer
Breast Neoplasms - diet therapy
Breast Neoplasms - mortality
Breast Neoplasms - therapy
China - epidemiology
Cohort Studies
Combined Modality Therapy
Correlation analysis
Feeding. Feeding behavior
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Humans
Middle Aged
Mortality
Neoplasm Recurrence, Local
Nutrition
Prospective Studies
Risk
Risk factors
Soy Foods
Soy products
Survival Analysis
Survivor
United States - epidemiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Soy isoflavones have antiestrogenic and anticancer properties but also possess estrogen-like properties, which has raised concern about soy food consumption among breast cancer survivors. We prospectively evaluated the association between postdiagnosis soy food consumption and breast cancer outcomes among US and Chinese women by using data from the After Breast Cancer Pooling Project. The analysis included 9514 breast cancer survivors with a diagnosis of invasive breast cancer between 1991 and 2006 from 2 US cohorts and 1 Chinese cohort. Soy isoflavone intake (mg/d) was measured with validated food-frequency questionnaires. HRs and 95% CIs were estimated by using delayed-entry Cox regression models, adjusted for sociodemographic, clinical, and lifestyle factors. After a mean follow-up of 7.4 y, we identified 1171 total deaths (881 from breast cancer) and 1348 recurrences. Despite large differences in soy isoflavone intake by country, isoflavone consumption was inversely associated with recurrence among both US and Chinese women, regardless of whether data were analyzed separately by country or combined. No heterogeneity was observed. In the pooled analysis, consumption of ≥10 mg isoflavones/d was associated with a nonsignificant reduced risk of all-cause (HR: 0.87; 95% CI: 0.70, 1.10) and breast cancer-specific (HR: 0.83; 95% CI: 0.64, 1.07) mortality and a statistically significant reduced risk of recurrence (HR: 0.75; 95% CI: 0.61, 0.92). In this large study of combined data on US and Chinese women, postdiagnosis soy food consumption of ≥10 mg isoflavones/d was associated with a nonsignificant reduced risk of breast cancer-specific mortality and a statistically significant reduced risk of recurrence.
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.112.035972