Nasopharyngectomy for locally advanced recurrent nasopharyngeal carcinoma: Exploring the limits

Background The purpose of this study was to present the outcome of nasopharyngectomy for locally advanced recurrent nasopharyngeal carcinoma (NPC). Methods Between 2000 and 2010, patients with locally advanced recurrent NPC were recruited. Surgical outcomes were analyzed retrospectively. Results Amo...

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Bibliographic Details
Published in:Head & neck 2012-07, Vol.34 (7), p.923-928
Main Authors: Chan, Jimmy Yu Wai, Chow, Velda Ling Yu, Tsang, Raymond, Wei, William I.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carcinoma
craniofacial resection
Female
Follow-Up Studies
Humans
Male
maxillary swing operation
Medical sciences
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - surgery
Neoplasm Recurrence, Local - surgery
Otorhinolaryngology. Stomatology
Pharyngectomy - methods
Prognosis
recurrent nasopharyngeal carcinoma
Retrospective Studies
Survival Analysis
Treatment Outcome
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
vastus lateralis muscle flap
Young Adult
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Summary:Background The purpose of this study was to present the outcome of nasopharyngectomy for locally advanced recurrent nasopharyngeal carcinoma (NPC). Methods Between 2000 and 2010, patients with locally advanced recurrent NPC were recruited. Surgical outcomes were analyzed retrospectively. Results Among the 22 patients recruited, all had extended resections via the maxillary swing approach, resulting in exposure of the petrosal part of the internal carotid artery (ICA). One patient required craniofacial approach for tumor removal. The curative resection rate was 81.8%. Free flap reconstruction was performed in all cases. The mean follow‐up period was 38.8 months. All patients survived. Although 1 patient developed local and systemic tumor recurrence, the rest of the patients remained disease free. There was no carotid blowout or osteoradionecrosis of the skull base. Conclusion Curative resections can be achieved for locally advanced recurrent NPC with good outcome. Microvascular free flap reconstruction is crucial to prevent carotid artery blowout and osteoradionecrosis of the skull base. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21855