Oestrogen's regulation of fat metabolism during exercise and gender specific effects

Highlights ► In muscle oestrogen increases the expression and protein content of PPARα and PPARδ⋅ ► Oestrogen's direct/indirect genomic action increases LCFA transport and oxidation. ► During exercise, oestrogen promotes the mobilisation of adipose stores. ► Oestrogen increases gene expression...

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Bibliographic Details
Published in:Current opinion in pharmacology 2012-06, Vol.12 (3), p.363-371
Main Authors: Oosthuyse, Tanja, Bosch, Andrew N
Format: Article
Language:English
Subjects:
Adipocytes, White - drug effects
Adipocytes, White - metabolism
Animals
Estrogen Receptor alpha - agonists
Estrogen Receptor alpha - metabolism
Estrogens - metabolism
Estrogens - pharmacology
Exercise
Female
Gene Expression Regulation - drug effects
Heat-Shock Proteins - genetics
Heat-Shock Proteins - metabolism
Humans
Internal Medicine
Lipid Metabolism - drug effects
Lipolysis - drug effects
Male
Medical Education
Motor Activity
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Organ Specificity
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Sex Characteristics
Signal Transduction - drug effects
Sterol Esterase - genetics
Sterol Esterase - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Highlights ► In muscle oestrogen increases the expression and protein content of PPARα and PPARδ⋅ ► Oestrogen's direct/indirect genomic action increases LCFA transport and oxidation. ► During exercise, oestrogen promotes the mobilisation of adipose stores. ► Oestrogen increases gene expression for IMCL storage to enhance LCFA availability. ► Oestrogen and catechol-oestrogen metabolite activates AMPK via non-genomic means.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2012.02.008