MAGE-3 and MAGE-4 genes as possible markers for early detection of metastases in hepatitis C virus Egyptian patients complicated by hepatocellular carcinoma

The dissemination of hepatocellular carcinoma (HCC) cells into the circulation plays a critical role in post-operative recurrence and metastasis. Early detection of metastatic tumor cells is critical to identify HCC patients at high risk of relapse. MAGE-3 and -4 genes were evaluated by reverse tran...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2012-06, Vol.29 (2), p.994-999
Main Authors: Hussein, Yousri M., Ghareib, Amal F., Mohamed, Randa H., Radwan, Mohamed I., Elsawy, Wael H.
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - genetics
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - secondary
Case-Control Studies
Cohort Studies
Early Detection of Cancer
Egypt
Female
Follow-Up Studies
Gene expression
Hematology
Hepacivirus - pathogenicity
Hepatitis C - complications
Hepatitis C - genetics
Hepatitis C - virology
Hepatitis C virus
Hepatocellular carcinoma
Humans
Internal Medicine
Liver - metabolism
Liver Cirrhosis - genetics
Liver Cirrhosis - pathology
Liver Cirrhosis - virology
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Metastases
Middle Aged
Neoplasm Metastasis
Neoplasm Proteins - genetics
Oncology
Original Paper
Pathology
Peripheral blood
Polymerase chain reaction
Prognosis
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Reverse transcription
Risk factors
RNA, Messenger - genetics
Tumor cells
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Summary:The dissemination of hepatocellular carcinoma (HCC) cells into the circulation plays a critical role in post-operative recurrence and metastasis. Early detection of metastatic tumor cells is critical to identify HCC patients at high risk of relapse. MAGE-3 and -4 genes were evaluated by reverse transcription polymerase chain reaction for the possibility of using them as new markers for early detection of metastases in 160 chronic HCV Egyptian patients, 115 of them were complicated with HCC. The expressions of MAGE-3 and MAGE-4 mRNA in peripheral blood of patients with metastatic HCC were 36 and 52%, respectively. While the expressions of MAGE-3 and MAGE-4 mRNA in peripheral blood of patients with localized HCC were 12.5 and 15%, respectively. Moreover, at least one type of mRNA was found in the peripheral blood of 68% of the metastatic HCC patients and in 20% of the localized HCC patients. While neither the controls nor the cirrhotic patients show expression of MAGE-4 mRNA in their peripheral blood. MAGE-3 and MAGE-4 may be a promising diagnostic tool for monitoring the prognosis of HCC patients and early detection of occult hematogenous metastasis of HCC.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-011-9917-9