Prognostic significance of serum cystatin C in multiple myeloma

Multiple myeloma (MM) is frequently complicated by renal insufficiency, which is associated with an unfavorable prognosis. Serum cystatin C is a new and accurate marker of glomerular filtration rate. Global gene expression analysis has revealed serum cystatin C as one of the most highly upregulated...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2012-05, Vol.95 (5), p.545-550
Main Authors: Nückel, Holger, Langer, Christian, Herget-Rosenthal, Stefan, Wichert, Marc, Assert, Roland, Döhner, Hartmut, Dührsen, Ulrich, Liebisch, Peter
Format: Article
Language:English
Subjects:
Albumin
Antineoplastic Agents, Alkylating - therapeutic use
Autografts
beta 2-microglobulin
Biological and medical sciences
Calcium
Creatinine
cystatin C
Cystatin C - blood
Data processing
Female
Gene expression
genomics
Glomerular filtration rate
Hematologic and hematopoietic diseases
Hematology
Hemoglobin
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocytes
Male
Medical sciences
Medicine
Medicine & Public Health
Melphalan
Melphalan - therapeutic use
Middle Aged
Multiple myeloma
Multiple Myeloma - blood
Multiple Myeloma - diagnosis
Multiple Myeloma - drug therapy
Multiple Myeloma - surgery
Oncology
Original Article
Prognosis
Renal function
Renal insufficiency
Serum levels
Stem Cell Transplantation
Survival
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multiple myeloma (MM) is frequently complicated by renal insufficiency, which is associated with an unfavorable prognosis. Serum cystatin C is a new and accurate marker of glomerular filtration rate. Global gene expression analysis has revealed serum cystatin C as one of the most highly upregulated genes in MM. Recent data have shown serum cystatin C as an independent prognostic marker in MM. To further elucidate the prognostic significance of serum cystatin C, we investigated pretreatment serum cystatin C levels in 68 newly diagnosed patients homogeneously treated with high-dose melphalan followed by autologous stem cell transplantation. Median serum cystatin C level in MM patients was significantly higher than in the 66 healthy controls (1.07 vs. 0.74 mg/L [ p  = 0.002]). Median serum cystatin C levels significantly increased with higher International Staging System (ISS) stages (stage I 0.72 mg/L; stage II 0.89 mg/L; stage III 1.28 mg/L; p  
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-012-1049-2