Predicting response to therapy in chronic hepatitis C: An approach combining interleukin-28B gene polymorphisms and clinical data

Background and Aim:  Polymorphisms at the interleukin‐28B (IL28B) gene predict therapeutic response in chronic hepatitis C virus genotype 1 (CHC‐1) infection. The aim of the present study was to establish whether a unique single‐nucleotide polymorphism (SNP) represents the whole predictive value of...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2012-02, Vol.27 (2), p.279-285
Main Authors: Ladero, José M, Martin, Elena García, Fernández, Cristina, Carballo, Miguel, Devesa, María J, Martínez, Carmen, Suárez, Avelina, Díaz-Rubio, Manuel, Agúndez, José A
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Alanine transaminase
Alkaline phosphatase
Antiviral Agents - therapeutic use
Aspartate aminotransferase
Biomarkers - blood
Chi-Square Distribution
Cholesterol
Chronic infection
Data processing
Drug Therapy, Combination
Female
gamma -Glutamylcyclotransferase
Gene Frequency
Gene polymorphism
Haplotypes
Hepacivirus - drug effects
Hepacivirus - genetics
Hepatitis C
Hepatitis C virus
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - immunology
Humans
Interferon
Interferon alpha-2
Interferon-alpha - therapeutic use
interferon-λ3
Interferons
interleukin-28B gene
Interleukins - genetics
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Patient Selection
pegylated interferon
Phenotype
Polyethylene Glycols - therapeutic use
Polymorphism, Single Nucleotide
Recombinant Proteins - therapeutic use
Recurrence
Ribavirin
Ribavirin - therapeutic use
RNA, Viral - blood
Single-nucleotide polymorphism
Spain
Time Factors
Treatment Outcome
Viral Load
Young Adult
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Summary:Background and Aim:  Polymorphisms at the interleukin‐28B (IL28B) gene predict therapeutic response in chronic hepatitis C virus genotype 1 (CHC‐1) infection. The aim of the present study was to establish whether a unique single‐nucleotide polymorphism (SNP) represents the whole predictive value of the IL28B haplotype for sustained viral response (SVR) and primary non‐response (PNR). Methods:  SNP rs12979860 and rs8099917 were determined by TaqMan assays in 110 CHC‐1 Caucasian patients treated with pegylated interferon plus ribavirin. Results:  There were 51 SVR, 43 PNR, and 16 relapses. Baseline predictors of SVR were rs12979860CC genotype (P = 0.008), viral load
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2011.06834.x