Long-term clinical and angiographic outcomes of patients with sirolimus-eluting stent fracture

Abstract Background There is limited data on the long-term outcomes of patients with sirolimus-eluting stent (SES) fracture. Methods After performing index percutaneous coronary intervention (PCI) with SES from Dec. 2003 to Dec. 2007, the patients with stent fracture (SF) detected by angiography at...

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Bibliographic Details
Published in:International journal of cardiology 2012-06, Vol.158 (1), p.83-87
Main Authors: Kim, Ung, Kim, Doo-Il, Kim, Dong-Kie, Seol, Sang-Hoon, Jang, Jae-Sik, Yang, Tae-Hyun, Kim, Dae-Kyeong, Kim, Dong-Soo, Min, Ho-Ki, Choi, Kang-Joo
Format: Article
Language:English
Subjects:
Aged
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Cardiovascular system
Coronary Angiography
Drug-eluting stent
Drug-Eluting Stents
Female
Follow-Up Studies
Fracture
Humans
In-stent restenosis
Injuries of the limb. Injuries of the spine
Investigative techniques, diagnostic techniques (general aspects)
MACE
Male
Medical sciences
Middle Aged
Outcomes
Pharmacology. Drug treatments
Prosthesis Failure
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Sirolimus - administration & dosage
Time Factors
Traumas. Diseases due to physical agents
Treatment Outcome
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Summary:Abstract Background There is limited data on the long-term outcomes of patients with sirolimus-eluting stent (SES) fracture. Methods After performing index percutaneous coronary intervention (PCI) with SES from Dec. 2003 to Dec. 2007, the patients with stent fracture (SF) detected by angiography at follow-up or adverse events were enrolled. SF was angiographically defined as complete or partial separation of the stent and this had been contiguous after stenting. The patients were divided into two groups as SF without in-stent restenosis (ISR) (Group 1, n = 55) and SF with ISR (Group 2, n = 44) and the patients were clinically and angiographically followed up after the detection of SF. The major adverse cardiovascular events (MACE), including cardiac death, myocardial infarction (MI), target vessel revascularization (TVR), and stent thrombosis (ST) were determined. Results At SF detection, most patients were asymptomatic (92.7% in Group 1 vs. 43.2% in Group 2, p = 0.001). Acute coronary syndrome developed in 18.2% of Group 2, but it developed in only 1.8% of the patients of Group 1. Clinical follow-up was done in all patients for 675 ± 375 days from SF detection. From the detection of SF, MACEs were noted in 32.3% of the patients (10.9% in Group 1 vs. 59.1% in Group 2, p = 0.001), mostly from TVR (9.1% in Group 1 vs. 54.5% in Group 2, p = 0.001). Conclusion The long-term follow-up results of SF after SES implantation show an increased risk of adverse cardiac events, and especially for the patients with ISR.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2011.01.013