The association between hepatitis C virus infection, genetic polymorphisms of oxidative stress genes and B-cell non-Hodgkin’s lymphoma risk in Egypt

► We study NHL risk conferred by HCV infection and oxidative stress genes polymorphism. ► HCV infection is a risk factor for NHL in Egypt. ► Concomitant HCV infection and GPX1 gene polymorphism have a pronounced NHL risk. ► Combined HCV infection and MPO gene polymorphism have a synergetic risk for...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2012-08, Vol.12 (6), p.1189-1194
Main Authors: Farawela, Hala, Khorshied, Mervat, Shaheen, Iman, Gouda, Heba, Nasef, Aya, Abulata, Nelly, Mahmoud, Hebat-Allah, Zawam, Hamdy M., Mousa, Somaia M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antioxidant enzymes
Antioxidants
B-NHL
Case-Control Studies
catalase
Chi-Square Distribution
confidence interval
DNA Mutational Analysis
Egypt - epidemiology
etiological agents
Female
genes
Genetic polymorphism
Genetic Predisposition to Disease
Genotype
glutathione peroxidase
HCV
Hepatitis C virus
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - epidemiology
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - metabolism
Humans
inducible nitric oxide synthase
Lymphoma, B-Cell - epidemiology
Lymphoma, B-Cell - genetics
Lymphoma, B-Cell - metabolism
Lymphoma, B-Cell - virology
Male
Middle Aged
Mutation
myeloperoxidase
NHL risk
non-Hodgkin lymphoma
odds ratio
oxidative stress
Oxidative Stress - genetics
Oxidative stress genes
Oxidoreductases - genetics
patients
Polymorphism, Genetic
Risk
risk factors
screening
superoxide dismutase
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Summary:► We study NHL risk conferred by HCV infection and oxidative stress genes polymorphism. ► HCV infection is a risk factor for NHL in Egypt. ► Concomitant HCV infection and GPX1 gene polymorphism have a pronounced NHL risk. ► Combined HCV infection and MPO gene polymorphism have a synergetic risk for NHL. Hepatitis C virus (HCV) has been postulated to be an etiological agent for lymphoid malignancies. Polymorphisms in oxidative stress genes as; superoxide dismutase (SOD2), glutathione peroxidase (GPX1), catalase (CAT), myeloperoxidase (MPO) and nitric oxide synthase (NOS2) may influence non-Hodgkin’s lymphoma (NHL) risk. HCV screening and polymorphisms in these five genes coding for antioxidant enzymes were studied in 100 Egyptian patients with B cell-NHL and 100 controls to clarify the association between HCV infection, oxidative stress genes polymorphisms and B cell-NHL risk. A significantly higher prevalence of HCV infection was detected among NHL patients relative to controls and this carried a 14-fold increased NHL risk (odds ratio (OR)=14.3, 95% confidence interval (CI)=5.4–38.3, p
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2012.04.007