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Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs
A study was conducted to investigate the effects of l -arginine (Arg) on performance and immune function in cyclophosphamide (CY) immunosuppressed weaned pigs. The weaned pigs were allotted randomly into one of three treatments, including: (1) non-challenged control; (2) CY-challenged group; and (3)...
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| Published in: | Amino acids 2009-10, Vol.37 (4), p.643-651 |
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| cites | cdi_FETCH-LOGICAL-c404t-4ad366db6ac18f5040328192fadc2a2deb0f103ae17ad53762b899c14c85cd793 |
| container_end_page | 651 |
| container_issue | 4 |
| container_start_page | 643 |
| container_title | Amino acids |
| container_volume | 37 |
| creator | Han, J. Liu, Y. L. Fan, W. Chao, J. Hou, Y. Q. Yin, Y. L. Zhu, H. L. Meng, G. Q. Che, Z. Q. |
| description | A study was conducted to investigate the effects of
l
-arginine (Arg) on performance and immune function in cyclophosphamide (CY) immunosuppressed weaned pigs. The weaned pigs were allotted randomly into one of three treatments, including: (1) non-challenged control; (2) CY-challenged group; and (3) CY + 0.5% Arg. On days 14 and 21 of the trial, pigs were injected with CY or sterile saline. Blood samples were obtained on days 21 and 28 of the trial for further analysis. On day 28, delayed-type hypersensitivity reaction was evaluated. Arg alleviated the decrease of average daily gain (
P
|
| doi_str_mv | 10.1007/s00726-008-0184-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1019664809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1019664809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-4ad366db6ac18f5040328192fadc2a2deb0f103ae17ad53762b899c14c85cd793</originalsourceid><addsrcrecordid>eNp1kU9r3DAQxUVoSTZ_PkAuwdBLLmpGsixLx5KkaSGQS3I2sjTeaLFlV7Jb9ttXZhdaCr2MDu-nN495hFwz-MwA6ruUB5cUQFFgSlB9QjZMlIpypvUHsgFdaipExc7IeUo7AMYVk6fkjCnFGVR8Q3YPHmcT90VPTdz64AMWaZmmHgcMs5n9GArT9_jTmxlT4YdhCeMKRExpFX1wi0VXtPvC7m0_Tu9jmt7N4B1mrfiFJmR18tt0ST52pk94dXwvyNvXx9f7b_T55en7_ZdnagWImQrjSildK41lqqtAQJlTa94ZZ7nhDlvoGJQGWW1cVdaSt0pry4RVlXW1Li_I7cF3iuOPBdPcDD5Z7PucZFxSw4BpKYWCFf30D7oblxhyukzpStZVqatMsQNl45hSxK6Zoh_y0TLUrEU0hyKaXESzFtGszjdH56Ud0P35cbx8BvgBSFkKW4x_r_6f62-EbZUi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1095675395</pqid></control><display><type>article</type><title>Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs</title><source>Springer Link</source><creator>Han, J. ; Liu, Y. L. ; Fan, W. ; Chao, J. ; Hou, Y. Q. ; Yin, Y. L. ; Zhu, H. L. ; Meng, G. Q. ; Che, Z. Q.</creator><creatorcontrib>Han, J. ; Liu, Y. L. ; Fan, W. ; Chao, J. ; Hou, Y. Q. ; Yin, Y. L. ; Zhu, H. L. ; Meng, G. Q. ; Che, Z. Q.</creatorcontrib><description><![CDATA[A study was conducted to investigate the effects of
l
-arginine (Arg) on performance and immune function in cyclophosphamide (CY) immunosuppressed weaned pigs. The weaned pigs were allotted randomly into one of three treatments, including: (1) non-challenged control; (2) CY-challenged group; and (3) CY + 0.5% Arg. On days 14 and 21 of the trial, pigs were injected with CY or sterile saline. Blood samples were obtained on days 21 and 28 of the trial for further analysis. On day 28, delayed-type hypersensitivity reaction was evaluated. Arg alleviated the decrease of average daily gain (
P
< 0.05) induced by CY challenge from days 21 to 28. Arg mitigated the CY-induced decrease of total white blood cell numbers (
P
< 0.05) on day 28 and improved the lymphocyte percentage on day 21 (
P
< 0.05). Arg increased the delayed-type hypersensitivity reaction (
P
< 0.05), and attenuated the decrease of bovine serum albumin antibody level caused by CY treatment (
P
< 0.05) on day 28. In addition, Arg elevated the levels of serum interleukin-2 and interferon-γ (
P
< 0.05) on day 28, and mitigated the decrease of serum interferon-γ level on day 21 (
P
< 0.05). These results indicate that Arg supplementation has beneficial effects in attenuating the immunosuppressive effects of CY challenge, therefore improving growth performance of young pigs.]]></description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-008-0184-9</identifier><identifier>PMID: 18821052</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Animals ; Arginine - administration & dosage ; Biochemical Engineering ; Biochemistry ; Biomedical and Life Sciences ; Blood Cell Count ; Body Weight - drug effects ; Body Weight - physiology ; Cell Proliferation - drug effects ; Concanavalin A - pharmacology ; Cyclophosphamide - administration & dosage ; Cyclophosphamide - pharmacology ; Dietary Supplements ; Hogs ; Hypersensitivity, Delayed - immunology ; Hypersensitivity, Delayed - metabolism ; Immune system ; Immune Tolerance - drug effects ; Immunoglobulin G - blood ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - pharmacology ; Interferon-gamma - immunology ; Interferon-gamma - metabolism ; Interleukin-2 - immunology ; Interleukin-2 - metabolism ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Life Sciences ; Mitogens - pharmacology ; Neurobiology ; Original Article ; Phytohemagglutinins - pharmacology ; Proteomics ; Sus scrofa - growth & development ; Sus scrofa - immunology ; Weaning</subject><ispartof>Amino acids, 2009-10, Vol.37 (4), p.643-651</ispartof><rights>Springer-Verlag 2008</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-4ad366db6ac18f5040328192fadc2a2deb0f103ae17ad53762b899c14c85cd793</citedby><cites>FETCH-LOGICAL-c404t-4ad366db6ac18f5040328192fadc2a2deb0f103ae17ad53762b899c14c85cd793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18821052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, J.</creatorcontrib><creatorcontrib>Liu, Y. L.</creatorcontrib><creatorcontrib>Fan, W.</creatorcontrib><creatorcontrib>Chao, J.</creatorcontrib><creatorcontrib>Hou, Y. Q.</creatorcontrib><creatorcontrib>Yin, Y. L.</creatorcontrib><creatorcontrib>Zhu, H. L.</creatorcontrib><creatorcontrib>Meng, G. Q.</creatorcontrib><creatorcontrib>Che, Z. Q.</creatorcontrib><title>Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><addtitle>Amino Acids</addtitle><description><![CDATA[A study was conducted to investigate the effects of
l
-arginine (Arg) on performance and immune function in cyclophosphamide (CY) immunosuppressed weaned pigs. The weaned pigs were allotted randomly into one of three treatments, including: (1) non-challenged control; (2) CY-challenged group; and (3) CY + 0.5% Arg. On days 14 and 21 of the trial, pigs were injected with CY or sterile saline. Blood samples were obtained on days 21 and 28 of the trial for further analysis. On day 28, delayed-type hypersensitivity reaction was evaluated. Arg alleviated the decrease of average daily gain (
P
< 0.05) induced by CY challenge from days 21 to 28. Arg mitigated the CY-induced decrease of total white blood cell numbers (
P
< 0.05) on day 28 and improved the lymphocyte percentage on day 21 (
P
< 0.05). Arg increased the delayed-type hypersensitivity reaction (
P
< 0.05), and attenuated the decrease of bovine serum albumin antibody level caused by CY treatment (
P
< 0.05) on day 28. In addition, Arg elevated the levels of serum interleukin-2 and interferon-γ (
P
< 0.05) on day 28, and mitigated the decrease of serum interferon-γ level on day 21 (
P
< 0.05). These results indicate that Arg supplementation has beneficial effects in attenuating the immunosuppressive effects of CY challenge, therefore improving growth performance of young pigs.]]></description><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Arginine - administration & dosage</subject><subject>Biochemical Engineering</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood Cell Count</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>Cell Proliferation - drug effects</subject><subject>Concanavalin A - pharmacology</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Cyclophosphamide - pharmacology</subject><subject>Dietary Supplements</subject><subject>Hogs</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Hypersensitivity, Delayed - metabolism</subject><subject>Immune system</subject><subject>Immune Tolerance - drug effects</subject><subject>Immunoglobulin G - blood</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Interferon-gamma - immunology</subject><subject>Interferon-gamma - metabolism</subject><subject>Interleukin-2 - immunology</subject><subject>Interleukin-2 - metabolism</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Life Sciences</subject><subject>Mitogens - pharmacology</subject><subject>Neurobiology</subject><subject>Original Article</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Proteomics</subject><subject>Sus scrofa - growth & development</subject><subject>Sus scrofa - immunology</subject><subject>Weaning</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp1kU9r3DAQxUVoSTZ_PkAuwdBLLmpGsixLx5KkaSGQS3I2sjTeaLFlV7Jb9ttXZhdaCr2MDu-nN495hFwz-MwA6ruUB5cUQFFgSlB9QjZMlIpypvUHsgFdaipExc7IeUo7AMYVk6fkjCnFGVR8Q3YPHmcT90VPTdz64AMWaZmmHgcMs5n9GArT9_jTmxlT4YdhCeMKRExpFX1wi0VXtPvC7m0_Tu9jmt7N4B1mrfiFJmR18tt0ST52pk94dXwvyNvXx9f7b_T55en7_ZdnagWImQrjSildK41lqqtAQJlTa94ZZ7nhDlvoGJQGWW1cVdaSt0pry4RVlXW1Li_I7cF3iuOPBdPcDD5Z7PucZFxSw4BpKYWCFf30D7oblxhyukzpStZVqatMsQNl45hSxK6Zoh_y0TLUrEU0hyKaXESzFtGszjdH56Ud0P35cbx8BvgBSFkKW4x_r_6f62-EbZUi</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Han, J.</creator><creator>Liu, Y. L.</creator><creator>Fan, W.</creator><creator>Chao, J.</creator><creator>Hou, Y. Q.</creator><creator>Yin, Y. L.</creator><creator>Zhu, H. L.</creator><creator>Meng, G. Q.</creator><creator>Che, Z. Q.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20091001</creationdate><title>Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs</title><author>Han, J. ; Liu, Y. L. ; Fan, W. ; Chao, J. ; Hou, Y. Q. ; Yin, Y. L. ; Zhu, H. L. ; Meng, G. Q. ; Che, Z. 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L.</au><au>Fan, W.</au><au>Chao, J.</au><au>Hou, Y. Q.</au><au>Yin, Y. L.</au><au>Zhu, H. L.</au><au>Meng, G. Q.</au><au>Che, Z. Q.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs</atitle><jtitle>Amino acids</jtitle><stitle>Amino Acids</stitle><addtitle>Amino Acids</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>37</volume><issue>4</issue><spage>643</spage><epage>651</epage><pages>643-651</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract><![CDATA[A study was conducted to investigate the effects of
l
-arginine (Arg) on performance and immune function in cyclophosphamide (CY) immunosuppressed weaned pigs. The weaned pigs were allotted randomly into one of three treatments, including: (1) non-challenged control; (2) CY-challenged group; and (3) CY + 0.5% Arg. On days 14 and 21 of the trial, pigs were injected with CY or sterile saline. Blood samples were obtained on days 21 and 28 of the trial for further analysis. On day 28, delayed-type hypersensitivity reaction was evaluated. Arg alleviated the decrease of average daily gain (
P
< 0.05) induced by CY challenge from days 21 to 28. Arg mitigated the CY-induced decrease of total white blood cell numbers (
P
< 0.05) on day 28 and improved the lymphocyte percentage on day 21 (
P
< 0.05). Arg increased the delayed-type hypersensitivity reaction (
P
< 0.05), and attenuated the decrease of bovine serum albumin antibody level caused by CY treatment (
P
< 0.05) on day 28. In addition, Arg elevated the levels of serum interleukin-2 and interferon-γ (
P
< 0.05) on day 28, and mitigated the decrease of serum interferon-γ level on day 21 (
P
< 0.05). These results indicate that Arg supplementation has beneficial effects in attenuating the immunosuppressive effects of CY challenge, therefore improving growth performance of young pigs.]]></abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>18821052</pmid><doi>10.1007/s00726-008-0184-9</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Amino acids, 2009-10, Vol.37 (4), p.643-651 |
| issn | 0939-4451 1438-2199 |
| language | eng |
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| source | Springer Link |
| subjects | Analytical Chemistry Animals Arginine - administration & dosage Biochemical Engineering Biochemistry Biomedical and Life Sciences Blood Cell Count Body Weight - drug effects Body Weight - physiology Cell Proliferation - drug effects Concanavalin A - pharmacology Cyclophosphamide - administration & dosage Cyclophosphamide - pharmacology Dietary Supplements Hogs Hypersensitivity, Delayed - immunology Hypersensitivity, Delayed - metabolism Immune system Immune Tolerance - drug effects Immunoglobulin G - blood Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-2 - immunology Interleukin-2 - metabolism Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Life Sciences Mitogens - pharmacology Neurobiology Original Article Phytohemagglutinins - pharmacology Proteomics Sus scrofa - growth & development Sus scrofa - immunology Weaning |
| title | Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs |
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