Dietary l-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs

A study was conducted to investigate the effects of l -arginine (Arg) on performance and immune function in cyclophosphamide (CY) immunosuppressed weaned pigs. The weaned pigs were allotted randomly into one of three treatments, including: (1) non-challenged control; (2) CY-challenged group; and (3)...

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Bibliographic Details
Published in:Amino acids 2009-10, Vol.37 (4), p.643-651
Main Authors: Han, J., Liu, Y. L., Fan, W., Chao, J., Hou, Y. Q., Yin, Y. L., Zhu, H. L., Meng, G. Q., Che, Z. Q.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animals
Arginine - administration & dosage
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Blood Cell Count
Body Weight - drug effects
Body Weight - physiology
Cell Proliferation - drug effects
Concanavalin A - pharmacology
Cyclophosphamide - administration & dosage
Cyclophosphamide - pharmacology
Dietary Supplements
Hogs
Hypersensitivity, Delayed - immunology
Hypersensitivity, Delayed - metabolism
Immune system
Immune Tolerance - drug effects
Immunoglobulin G - blood
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - pharmacology
Interferon-gamma - immunology
Interferon-gamma - metabolism
Interleukin-2 - immunology
Interleukin-2 - metabolism
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Life Sciences
Mitogens - pharmacology
Neurobiology
Original Article
Phytohemagglutinins - pharmacology
Proteomics
Sus scrofa - growth & development
Sus scrofa - immunology
Weaning
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Summary:A study was conducted to investigate the effects of l -arginine (Arg) on performance and immune function in cyclophosphamide (CY) immunosuppressed weaned pigs. The weaned pigs were allotted randomly into one of three treatments, including: (1) non-challenged control; (2) CY-challenged group; and (3) CY + 0.5% Arg. On days 14 and 21 of the trial, pigs were injected with CY or sterile saline. Blood samples were obtained on days 21 and 28 of the trial for further analysis. On day 28, delayed-type hypersensitivity reaction was evaluated. Arg alleviated the decrease of average daily gain ( P  
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-008-0184-9