SEM-induced shrinking of solid-state nanopores for single molecule detection

We have investigated the mechanism by which the diameter of solid-state nanopores is reduced by a scanning electron microscope. The process depends on beam parameters such as the accelerating voltage and electron flux and does not involve simple electron-beam-induced deposition of hydrocarbon contam...

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Published in:Nanotechnology 2011-10, Vol.22 (42), p.425302-1-10
Main Authors: Prabhu, Anmiv S, Freedman, Kevin J, Robertson, Joseph W F, Nikolov, Zhorro, Kasianowicz, John J, Kim, Min Jun
Format: Article
Language:English
Subjects:
Bacteriophage lambda - genetics
Beams (radiation)
Biosensing Techniques - methods
Deposition
DNA - analysis
DNA, Viral - analysis
Electric Conductivity
Electron density
Microscopy, Electron, Scanning - methods
Nanocomposites
Nanomaterials
Nanopores - ultrastructure
Nanostructure
Porosity
Scanning electron microscopy
Sensitivity and Specificity
Voltage
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cited_by cdi_FETCH-LOGICAL-c489t-a1c69f39ef11f5c798461991cf8639477751373fd5c0617b0309e559c09bc8ed3
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container_issue 42
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container_title Nanotechnology
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creator Prabhu, Anmiv S
Freedman, Kevin J
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description We have investigated the mechanism by which the diameter of solid-state nanopores is reduced by a scanning electron microscope. The process depends on beam parameters such as the accelerating voltage and electron flux and does not involve simple electron-beam-induced deposition of hydrocarbon contaminants. Instead, it is an energy-dependent process that involves material flow along the surface of the nanopore membrane. We also show that pores fabricated in this manner can detect double stranded DNA.
doi_str_mv 10.1088/0957-4484/22/42/425302
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source Institute of Physics:Jisc Collections:IOP Publishing Read and Publish 2024-2025 (Reading List)
subjects Bacteriophage lambda - genetics
Beams (radiation)
Biosensing Techniques - methods
Deposition
DNA - analysis
DNA, Viral - analysis
Electric Conductivity
Electron density
Microscopy, Electron, Scanning - methods
Nanocomposites
Nanomaterials
Nanopores - ultrastructure
Nanostructure
Porosity
Scanning electron microscopy
Sensitivity and Specificity
Voltage
title SEM-induced shrinking of solid-state nanopores for single molecule detection
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