SEM-induced shrinking of solid-state nanopores for single molecule detection

We have investigated the mechanism by which the diameter of solid-state nanopores is reduced by a scanning electron microscope. The process depends on beam parameters such as the accelerating voltage and electron flux and does not involve simple electron-beam-induced deposition of hydrocarbon contam...

Full description

Saved in:
Bibliographic Details
Published in:Nanotechnology 2011-10, Vol.22 (42), p.425302-1-10
Main Authors: Prabhu, Anmiv S, Freedman, Kevin J, Robertson, Joseph W F, Nikolov, Zhorro, Kasianowicz, John J, Kim, Min Jun
Format: Article
Language:English
Subjects:
Bacteriophage lambda - genetics
Beams (radiation)
Biosensing Techniques - methods
Deposition
DNA - analysis
DNA, Viral - analysis
Electric Conductivity
Electron density
Microscopy, Electron, Scanning - methods
Nanocomposites
Nanomaterials
Nanopores - ultrastructure
Nanostructure
Porosity
Scanning electron microscopy
Sensitivity and Specificity
Voltage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have investigated the mechanism by which the diameter of solid-state nanopores is reduced by a scanning electron microscope. The process depends on beam parameters such as the accelerating voltage and electron flux and does not involve simple electron-beam-induced deposition of hydrocarbon contaminants. Instead, it is an energy-dependent process that involves material flow along the surface of the nanopore membrane. We also show that pores fabricated in this manner can detect double stranded DNA.
ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/22/42/425302