Differentiation of subgroups of monosymptomatic enuresis according to prepulse inhibition of the startle reflex

Aim:  Monosymptomatic enuresis (ME) is a common disorder in children with serious social and psychological consequences. Treatment is usually initiated with desamino‐arginine vasopressin (dDAVP) and/or alarm therapy as first‐line treatment and imipramine as second‐line. All treatments have proven ef...

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Bibliographic Details
Published in:Acta Paediatrica 2012-07, Vol.101 (7), p.e304-e308
Main Authors: Eggert, Paul, Freischmidt, Sönke, Bismarck, Phillip v., Schulz-Jürgensen, Sebastian
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adolescent
Adrenergic Uptake Inhibitors - therapeutic use
Alarm therapy
Antidiuretic Agents - therapeutic use
Child
Clinical Alarms
Combined Modality Therapy
Deamino Arginine Vasopressin - therapeutic use
Desamino-arginine vasopressin
Drug therapy
Female
Humans
Imipramine
Imipramine - therapeutic use
Male
Monosymptomatic enuresis
Nocturnal Enuresis - etiology
Nocturnal Enuresis - psychology
Nocturnal Enuresis - therapy
Prospective Studies
Reactive Inhibition
Reflex, Startle
Treatment Outcome
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Summary:Aim:  Monosymptomatic enuresis (ME) is a common disorder in children with serious social and psychological consequences. Treatment is usually initiated with desamino‐arginine vasopressin (dDAVP) and/or alarm therapy as first‐line treatment and imipramine as second‐line. All treatments have proven efficacy, but are not successful with all patients. Therefore, a differentiation into subgroups according to treatment efficacy would be beneficial. Methods:  A group of patients resistant to first‐line treatment was treated with imipramine and compared with matched controls successfully treated with dDAVP and/or alarm therapy. Prepulse inhibition (PPI) to acoustic startle reflexes was measured in all patients. Results:  In a group of 23 nonresponders, the median PPI was 72% (range 43–94%) compared with the matched dDAVP/alarm – responders with a median PPI of 26% (range 0–61%) (p 
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2012.02624.x