Compared outcomes of very preterm infants born in 2000 and 2005

Aim:  To compare neonatal and 2‐year outcomes in very premature infants born 5 years apart. Methods:  Prospective observational study of infants born before 33 weeks’ gestation in 2000 or 2005 admitted to a neonatal intensive care unit in France. We collected perinatal data and evaluated motor, cogn...

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Bibliographic Details
Published in:Acta Paediatrica 2012-07, Vol.101 (7), p.731-735
Main Authors: Guerrot, Anne-Marie, Chadie, Alexandra, Torre, Stéphanie, Rondeau, Stéphane, Pinto Cardoso, Gaëlle, Abily-Donval, Lénaig, Marret, Stéphane
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones
Babies
Biological and medical sciences
Body Size
Cerebral palsy
Cerebral Palsy - epidemiology
Child, Preschool
Developmental Disabilities - epidemiology
Disability
Diseases of mother, fetus and pregnancy
Drug Utilization - trends
Follow-Up Studies
France - epidemiology
General aspects
Gynecology. Andrology. Obstetrics
Head - growth & development
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - epidemiology
Intellectual Disability - epidemiology
Medical sciences
Miscellaneous
Mortality
Motor Skills Disorders - epidemiology
Neurodevelopmental outcome
People with disabilities
Pregnancy. Fetus. Placenta
Prognosis
Prospective Studies
Public health. Hygiene
Public health. Hygiene-occupational medicine
Very premature
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Summary:Aim:  To compare neonatal and 2‐year outcomes in very premature infants born 5 years apart. Methods:  Prospective observational study of infants born before 33 weeks’ gestation in 2000 or 2005 admitted to a neonatal intensive care unit in France. We collected perinatal data and evaluated motor, cognitive, neurosensory and behavioural outcomes at 2 years of age. Results:  We included 170 infants in 2000 and 173 in 2005. The significant differences in neonatal outcomes were decreases in postnatal corticosteroid use and in percentage of infants with head circumference below the 3rd percentile on days 7 (25% vs. 13%) and 30 (30% vs. 17%). At 2 years of age, rates of follow‐up were 87% in 2000 and 94% in 2005. The cerebral palsy rate was 6% in both cohorts. The overall rate of motor disabilities diminished from 30% (41/137) to 18% (26/142), and the rate of mild motor disabilities decreased from 24% to 12%. Rates of cognitive, behavioural and neurosensorial impairments were similar. Conclusion:  Between 2000 and 2005, motor impairments at 2 years of age diminished in very preterm children (but not cerebral palsy rates). We observed a reduced use of postnatal corticosteroids and a decreased percentage of neonates with head circumference below the third percentile.
ISSN:0803-5253
1651-2227
DOI:10.1111/j.1651-2227.2012.02678.x