A survey on the use of gentamicin in infective endocarditis

US and European guidelines recommend a daily divided gentamicin dose (3 mg/kg in two or three equally divided doses) for the treatment of infective endocarditis caused by staphylococci or enterococci, but once-daily dosing (3 mg/kg/day) is recommended for streptococcal endocarditis. However, studies...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2012-07, Vol.31 (7), p.1413-1418
Main Authors: Béraud, G., Le Moal, G., Elsendoorn, A., Tattevin, P., Godet, C., Alfandari, S., Couet, W., Roblot, P., Roblot, F.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cardiology. Vascular system
Drug Therapy - methods
Endocardial and cardiac valvular diseases
Endocarditis
Endocarditis - drug therapy
Endocarditis - microbiology
France
Gentamicins - administration & dosage
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - microbiology
Guideline Adherence - statistics & numerical data
Heart
Humans
Infectious diseases
Internal Medicine
Medical Microbiology
Medical sciences
Pharmacology. Drug treatments
Physicians
Prescriptions - statistics & numerical data
Questionnaires
Surveys and Questionnaires
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Items that cite this one
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Summary:US and European guidelines recommend a daily divided gentamicin dose (3 mg/kg in two or three equally divided doses) for the treatment of infective endocarditis caused by staphylococci or enterococci, but once-daily dosing (3 mg/kg/day) is recommended for streptococcal endocarditis. However, studies have recommended the use of higher doses of gentamicin (4 or ≥5 mg/kg/day) administered once-daily. A survey was conducted in France by mailing a questionnaire to the 595 members of the French Infectious Disease Society regarding their gentamicin prescription patterns in infective endocarditis, focusing on the dosing regimen. The survey was answered by 137 physicians (23%). The proportions of physicians following guideline-based regimens were similar for each organism (30.9%, 38.8%, and 39.4% for staphylococci, enterococci, and streptococci, respectively [ p  = 0.26]). In contrast, the proportions of physicians following literature-based regimens were significantly different for each organism (59.6%, 42.5%, and 27.7% for staphylococci, enterococci, and streptococci, respectively [ p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-011-1458-9